He was the Italian Minister of Foreign Affairs in Giuseppe Zanardelli's period between 1901 and 1903, and signed the Triple Alliance (1882) renewal in 1902. Before that, he was deputy to the department of public works, elected in 1882. He became the Italian Minister of Public Works under Antonio Starabba, Marchese di Rudinì between March 1896 and December 1897. Between 1883 and 1901, he was the co-owner of the Prinetti & Stucchi automobile manufacturer. Prinetti left politics after being struck by apoplexy in 1904, and died in Rome four years later.
- Knight Grand Cordon of the imper Order of Saint Alexander Nevsky , July 1902.
- 1903 : Created Marquis by Royal decree.
- 1903 : Knight grand Cross in the Order of Saints Maurice and Lazarus.