He painted for the main church in Mirandola and the church in Vallalta. He painted a cycle of paintings about the Mysteries of the Rosary, once were around the altar dedicated to the Madonna del Rosario in the church of San Materno Vescovo in Melara. These are now found in Rovigo. He also painted two altarpieces destroyed in an 1851 fire at the church. Giuseppe's brother was a prelate in the town. He painted two altarpieces for Santa Maria in Vado: a Il mendico cacciato dal convitto di nozze and a Sacrifice of Melchisedec
He painted many portraits, including Girolamo Baruffaldi (Cento, 1736), Ferrante Borsetti, Pope Benedict XIV, and Bishop B. Barberini. Francesco Zucchi engraved many of his portraits. Ghedini helped illustrated the front page of an edition of Gerusalemme Liberata by Ricciardetto di N. Fortiguerri, also engraved by Zucchi.
- Gli artisti italiani e stranieri negli stati estensi catalogo storico ... By Giuseppe Campori, pages 242.
- Ventaglio Novanta Internet journal article on the “Misteri” di G. A. Ghedini; by Raffaele Ridolfi Ventaglio n. 40 - Dicembre 2009.
- Arte in Ariostea Archived October 19, 2010, at the Wayback Machine., short biography.
- Camillo Laderchi (1856). Abram Servadio, ed. La pittura ferrarese, memorie. Published in Ferrara, Digitized by Googlebooks from Oxford Library. p. 183.
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