|Chemical and physical data|
|Molar mass||295.419 g/mol|
|3D model (Jmol)||Interactive image|
Glemanserin (INN; MDL-11,939) is a drug which acts as a potent and selective 5-HT2A receptor antagonist. The first truly selective 5-HT2A ligand to be discovered, glemanserin resulted in the development of the widely used and even more potent and selective 5-HT2A receptor antagonist volinanserin (MDL-100,907), which is a fluorinated analogue. Though it was largely superseded in scientific research by volinanserin, glemanserin was investigated clinically for the treatment of generalized anxiety disorder. However, it was ultimately found to be ineffective and was not marketed.
- Mark W. Dudley; Norbert L. Wiech; Francis P. Miller; et al. (1988). "Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5-HT2 receptors". Drug Development Research. 13 (1): 29–43. doi:10.1002/ddr.430130104.
- Berend Olivier (10 July 1997). Serotonin Receptors and Their Ligands. Elsevier. p. 167. ISBN 978-0-444-82041-9. Retrieved 6 May 2012.
- Sramek JJ, Robinson RE, Suri A, Cutler NR (February 1995). "Efficacy trial of the 5-HT2 antagonist MDL 11,939 in patients with generalized anxiety disorder". Journal of Clinical Psychopharmacology. 15 (1): 20–2. doi:10.1097/00004714-199502000-00004. PMID 7714223.
|This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.|