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Gliese may refer to:

  • Rochus Gliese (1891—1978), a German actor, director, production designer, and art director
  • Wilhelm Gliese (1915–1993), a German astronomer, best known for the Gliese Catalogue of Nearby Stars
  • Gliese Catalogue of Nearby Stars, a modern star catalog of stars located within 25 parsecs of the Earth
  • Gliese 163, a red dwarf located 49 light years from the Sun
  • Gliese 581, a red dwarf orbited by several extra-solar planets, at least
  • Gliese 667, a triple star system in the constellation of Scorpius containing exoplanet GJ 667 Cc in one of the stars' habitable zone
  • Gliese 682, a red dwarf in the constellation of Scorpius with two candidate planets, one of which is in the star's habitable zone
  • Gliese 710, a star projected to pass through the Oort Cloud in 1.35 million years
  • Gliese 876, a red dwarf approximately 15 light-years away from Earth in the constellation of Aquarius
  • Gliese 623B, a small star in the constellation Hercules
  • Gliese 623B Consulting, a US based life sciences and medical devices consulting company