Globoidnan A

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Globoidnan A
Globoidnan A.svg
Names
IUPAC name
(2R)-(3,4-dihydroxyphenyl)-2-{[4-(3,4-dihydroxyphenyl)-6,7-dihydroxy-2-naphthoyl]oxy}propanoic acid
Identifiers
827322-48-5 YesY
ChemSpider 26333277 N
Jmol-3D images Image
PubChem 3013628
Properties
C26H20O10
Molar mass 492.44 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Globoidnan A is a lignan found in Eucalyptus globoidea, a tree native to Australia.

The molecule has been found to inhibit the action of HIV integrase,[1] an enzyme which is responsible for the introduction of HIV viral DNA into a host's cellular DNA. It is not known that globoidnan A inhibits the action of other retroviral integrases.

References[edit]

  1. ^ Ovenden SP, Yu J, Wan SS et al. (2004). "Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase". Phytochemistry 65 (24): 3255–59. doi:10.1016/j.phytochem.2004.10.006. PMID 15561191.