Globus pallidus

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Globus pallidus
Globus pallidus.svg
Globus pallidus (in red) shown within the brain
DA-loops in PD.svg
Dopamine-loops in Parkinson's disease
Part ofBasal ganglia
LatinGlobus pallidus
NeuroLex IDbirnlex_1234
Anatomical terms of neuroanatomy

The globus pallidus (GP), also known as paleostriatum or dorsal pallidum,[1] is a subcortical structure of the brain. It consists of two adjacent segments, one external, known in rodents simply as the globus pallidus, and one internal, known in rodents as the entopeduncular nucleus. It is part of the telencephalon, but retains close functional ties with the subthalamus in the diencephalon – both of which are part of the extrapyramidal motor system.[2] The globus pallidus is a major component of the basal ganglia, with principal inputs from the striatum, and principal direct outputs to the thalamus and the substantia nigra. The latter is made up of similar neuronal elements, has similar afferents from the striatum, similar projections to the thalamus, and has a similar synaptology. Neither receives direct cortical afferents, and both receive substantial additional inputs from the intralaminar thalamus.

Globus pallidus is Latin for "pale globe".


Transverse section of the globus pallidus from a structural MR image.
Transverse section of the globus pallidus from a structural MR image.

Pallidal nuclei are made up of the same neuronal components. In primates, almost all pallidal neurons are very large, parvalbumin-positive, with very large dendritic arborizations. These have the peculiarity of having the three-dimensional shape of flat discs, parallel to one another, parallel to the border of the pallidum[3] and perpendicular to the afferent striatopallidal axons.[4] There are only a few small local circuitry neurons.

The globus pallidus is traversed by the numerous myelinated axons of the striato-pallidonigral bundle that give it the pale appearance from which it is named.

The ultrastructure is very peculiar, as the long dendrites are everywhere, without discontinuity, covered by synapses.[5][6]


Microscopic image of the external globus pallidus (lower left of image) and putamen (upper right of image). H&E-LFB stain.

In the primate basal ganglia, the globus pallidus is divided into two parts by the medial medullary lamina. These are the internal globus pallidus (GPi) and the external globus pallidus (GPe); both are composed of closed nuclei surrounded by myelinic walls.

The ventral pallidum lies within the substantia innominata (Latin for unnamed substance) and receives efferent connections from the ventral striatum (the nucleus accumbens and the olfactory tubercle). It projects to the dorsomedial nucleus of the dorsal thalamus, which, in turn, projects to the prefrontal cortex; it also projects to the pedunculopontine nucleus and tegmental motor areas. Its function is to serve as a limbic-somatic motor interface, and it is involved in the planning and inhibition of movements from the dorsal striatopallidal complex.


The globus pallidus is a structure in the brain involved in the regulation of voluntary movement.[7] It is part of the basal ganglia, which, among many other functions, regulate movements that occur on the subconscious level. If the globus pallidus is damaged, it can cause movement disorders, as its regulatory function will be impaired. There may be cases in which damage is deliberately induced, as in a procedure known as a pallidotomy,[8] in which a lesion is created to reduce involuntary muscle tremors. When it comes to regulation of movement, the globus pallidus has a primarily inhibitory action that balances the excitatory action of the cerebellum. These two systems evolved to work in harmony with each other to allow smooth and controlled movements. Imbalances can result in tremors, jerks, and other movement problems, as seen in some people with progressive neurological disorders characterized by symptoms like tremors. The basal ganglia acts on a subconscious level, requiring no conscious effort to function. When someone makes a decision to engage in an activity such as petting a dog, for example, these structures help to regulate the movement to make it as smooth as possible, and to respond to sensory feedback. Likewise, the globus pallidus is involved in the constant subtle regulation of movement that allows people to walk and engage in a wide variety of other activities with a minimal level of disruption.[citation needed]

Pallidonigral pacemaker[edit]

The two pallidal nuclei and the two parts of the substantia nigra (the pars compacta and pars reticulata) constitute a high-frequency autonomous pacemaker.[9] (see primate basal ganglia#Pallidonigral set and pacemaker)

Common afferents[edit]

The two parts receive successively a large quantity of GABAergic axonal terminal arborisations from the striatum through the dense striato-pallidonigral bundle. The synaptology is very peculiar (see primate basal ganglia system).[5][6] The striatal afferents contribute more than 90% of synapses.[citation needed] The two pallidal nuclei receive dopaminergic axons from the pars compacta of the substantia nigra.

Coronal slices of human brain showing the basal ganglia.
ROSTRAL: striatum, globus pallidus (GPe and GPi)
CAUDAL: subthalamic nucleus (STN), substantia nigra (SN)
Overview of the main circuits of the basal ganglia. Globus pallidus externa and interna are shown in green. Picture shows 2 coronal slices that have been superimposed to include the involved basal ganglia structures, with + and – signs at the point of the arrows indicating, respectively, whether the pathway is excitatory or inhibitory in effect. Green arrows refer to excitatory glutamatergic pathways, red arrows refer to inhibitory GABAergic pathways and turquoise arrows refer to dopaminergic pathways that are excitatory on the direct pathway and inhibitory on the indirect pathway.


This area of the basal ganglia receives input from another area, called the striatum, which has two parts, the caudate nucleus and the putamen. This data is routed to the thalamus, either directly or indirectly. In the case of the interna, one area of the globus pallidus, the structure can feed directly to the thalamus. The externa, which lies on the outside of this structure, feeds information to the interna, where it can be passed on to the thalamus.


The origin of the name is not established. It was used by Joseph Dejerine (1906) but not by Santiago Ramón y Cajal (1909–1911).

As the elements in no way have the shape of a globe, throughout the 20th century scientists proposed a simpler term (a neuter adjective), pallidum (meaning "pale"). Propositions include those by Foix and Nicolesco (1925), the Vogts (1941), Crosby et al. (1962) and the Terminologia Anatomica.

For a long time the globus pallidus was linked to the putamen and termed the lentiform nucleus (nucleus lenticularis or lentiformis), a heterogeneous anatomical entity that is part of the striatum rather than the pallidum. The link with the substantia nigra pars reticulata was stressed very early on due to the similarities in dendritic arborisation (and they are sometimes known as the pallidonigral set) but, in spite of strong evidence, this association remains controversial.

See also[edit]


  1. ^ Reiner, Anton; Perkel, David J.; Bruce, Laura L.; Butler, Ann B.; Csillag, András; Kuenzel, Wayne; Medina, Loreta; Paxinos, George; Shimizu, Toru; Striedter, Georg; Wild, Martin; Ball, Gregory F.; Durand, Sarah; Gütürkün, Onur; Lee, Diane W.; Mello, Claudio V.; Powers, Alice; White, Stephanie A.; Hough, Gerald; Kubikova, Lubica; Smulders, Tom V.; Wada, Kazuhiro; Dugas-Ford, Jennifer; Husband, Scott; Yamamoto, Keiko; Yu, Jing; Siang, Connie; Jarvis, Erich D. (2004). "Revised Nomenclature for Avian Telencephalon and Some Related Brainstem Nuclei". The Journal of Comparative Neurology. 473 (3): 377–414. doi:10.1002/cne.20118. PMC 2518311. PMID 15116397.
  2. ^ Schünke, Michael; Ross, Lawrence M.; Schulte, Erik; Lamperti, Edward D.; Schumacher, Udo (2007). Theme atlas of anatomy: head and neuroanathomy. ISBN 9781588904416.
  3. ^ Yelnik, J., Percheron, G., and François, C. (1984) A Golgi analysis of the primate globus pallidus. II- Quantitative morphology and spatial orientation of dendritic arborisations. J. Comp. Neurol. 227:200–213
  4. ^ Percheron, G., Yelnik, J. and François. C. (1984) A Golgi analysis of the primate globus pallidus. III-Spatial organization of the striato-pallidal complex. J. Comp. Neurol. 227: 214–227
  5. ^ a b Fox, C.A., Andrade, A.N. Du Qui, I.J., Rafols, J.A. (1974) The primate globus pallidus. A Golgi and electron microscopic study. J. Hirnforsch. 15: 75–93
  6. ^ a b di Figlia, M., Pasik, P., Pasik, T. (1982) A Golgi and ultrastructural study of the monkey globus pallidus. J. Comp. Neurol. 212: 53–75
  7. ^ Gillies, M. J., Hyam, J. A., Weiss, A. R., Antoniades, C. A., Bogacz, R., Fitzgerald, J. J., … Green, A. L. (2017). The Cognitive Role of the Globus Pallidus interna; Insights from Disease States. Experimental Brain Research, 235(5), 1455–1465.>
  8. ^ McCartney, L. K., Bau K., Stewart K., Botha B., Morrow A., (2016), Pallidotomy as a treatment option for a complex patient with severe dystonia , Dev. Med. Child Neurol. 2016 58: (68–69)
  9. ^ Surmeier, D.J., Mercer, J.N. and Savio Chan, C. (2005) Autonomous pacemakers in the basal ganglia: who needs excitatory synapses anyway? Cur. Opin.Neurobiol. 15:312–318.

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