Glucagon rescue is the emergency injection of glucagon in case of severe diabetic hypoglycemia. It is needed during seizures and/or unconsciousness by an insulin user who is unable at that point to help themselves. Glucagon will facilitate the release of stored glucose back into the bloodstream, raising the blood glucose level.
Rescue has been simplified by the development of the glucagon hypoglycemia rescue kit, consisting of:
- biosynthetic human glucagon, in a freeze dried form within a vial,
- a sturdy syringe, pre-filled with a sterile diluting solution, and
- a conspicuous red or orange colored plastic storage box, which includes instructions.
At the first signs of hypoglycemia, an insulin user should treat it immediately by consuming carbohydrate to restore blood glucose to safe levels (thereby preventing progression to severe hypoglycemia). However, not all insulin users can feel and recognize the early signs, particularly when sleeping. This can quickly lead to an emergency resulting in unconsciousness, inability to swallow, seizures, and in extreme cases death. In the past, treatment consisted of intravenous delivery of dextrose (glucose) usually in the emergency room; however, the delay in treatment due to emergency response and transport to a medical facility is life-threatening.
Manufacturers of Glucagon Rescue Kits
Glucagon rescue kits are manufactured by Novo Nordisk and Eli Lilly and Company. Novo Nordisk manufactures the GlucaGen HypoKit and Eli Lilly and Company manufactures the Glucagon Emergency Rescue Kit.
Potential Issues with Glucagon Administration
Glucagon must be reconstituted using a multi-step process that requires the administrator to use a prepared syringe containing an inactive compound and a sealed dosage bottle of glucagon. After the contents of the syringe are injected into the glucagon bottle, the administrator must determine if the reconstitution appears appropriate: clear with a water-like consistency. This is a subjective assessment. The solution must be drawn back into the syringe, the injection site cleaned with alcohol, and then injected with sufficient force into fatty tissue. Individuals who have not performed this procedure before are at a disadvantage increased by the potential for severe hypoglycemia 
At the present time, there are no ready-made formulations of glucagon; within hours of reconstitution, the molecule will degrade into amyloid fibrils. Combined with the anxiety of performing a rescue is expense, bulkiness, and concerns over dosing correctly; fortunately, there is no biochemical way to overdose on intramuscularly injected glucagon.
Politics of Glucagon Rescue
Public awareness of other forms of life saving measures has increased dramatically in the past, such as:
- artificial respiration (or ‘mouth to mouth’)
- cardiopulmonary resuscitation (CPR)
- the Heimlich Maneuver, etc.
Glucagon ‘Mini-dose’ Instruction
The purpose of the off-label ‘mini-dose’ is to avoid an emergency condition that may require glucagon rescue. This might be needed in cases such as when a diabetic child is injected with insulin before breakfast, eats, and then vomits and cannot eat again: with the injected insulin working its way into the bloodstream and no carbohydrate to balance, there may soon be a hypoglycemic emergency.
Medical studies have shown that the mini-dose rescue is tolerated well and effective.
- User information for ‘GlucaGen HypoKit’ from Novo Nordisk
- User information for ‘Glucagon Emergency Kit’ from Eli Lilly and Company
- ‘GlucaGen Hypo Kit’ elearning course
- "Glucagon for Injection, rDNA formulation" (PDF). Lilly. Retrieved 23 February 2014.
- "Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas." Curr Diab Rep. 2012 Dec;12(6):705-10. doi:10.1007/s11892-012-0320-5
- Muchnick, Jeanne. "A User-Friendly Glucagon Kit?". InsulinNation. Retrieved 23 February 2014.
- Legal Rights of Students with Diabetes – American Diabetes Association
- Diabetes Care in Daycare: State Laws, Regulations, and Policies Related to Insulin and Glucagon Administration and Other Diabetes Care – American Diabetes Association
- Know Your Rights – American Diabetes Association
- Mini-Dose Glucagon Rescue for Hypoglycemia in Children With Type 1 Diabetes - Haymond and Schreiner. Diabetes Care 24(4):643-5.
The following scientific study papers may be of interest to those wishing to learn more about glucagon rescue in severe hypoglycemia:
- Kedia, Nitil (2011). "Treatment of severe diabetic hypoglycemia with glucagon: an underutilized therapeutic approach". Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 4: 337–46. doi:10.2147/DMSO.S20633. PMC 3180523. PMID 21969805.
- Pearson, T. (2008). "Glucagon as a Treatment of Severe Hypoglycemia: Safe and Efficacious but Underutilized". The Diabetes Educator 34 (1): 128–134. doi:10.1177/0145721707312400.
- Frier BM. Hypoglycemia in type 2 diabetes. Diabetic Hypoglycemia Jun 2008;2:2-7.
- Harrism, G.; Diment, A.; Sulway, M.; Wilkinson, M. (2001). "Glucagon administration - underevaluated and undertaught". Practical Diabetes International 18 (1): 22–25. doi:10.1002/pdi.138.
- Namba, Mitsuyoshi; Hanafusa, Toshiaki; Kono, Norio; Tarui, Seiichiro; The GL-G Hypoglycemia Study Group (1993). "Clinical evaluation of biosynthetic glucagon treatment for recovery from hypoglycemia developed in diabetic patients". Diabetes Research and Clinical Practice 19 (2): 133–138. doi:10.1016/0168-8227(93)90106-F.
- Vukmir, Rade B; Paris, Paul M; Yealy, Donald M (1991). "Glucagon: Prehospital therapy for hypoglycemia" (PDF). Annals of Emergency Medicine 20 (4): 375–379. doi:10.1016/S0196-0644(05)81658-0.
- Carstens, S; Sprehn, M (Apr–Dec 1998). "Prehospital treatment of severe hypoglycaemia: a comparison of intramuscular glucagon and intravenous glucose.". Prehospital and disaster medicine 13 (2-4): 44–50. PMID 10346406.