Potassium salt of glucoraphanin
Glucorafanin; 4-Methylsulfinylbutyl glucosinolate
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|Molar mass||436.49 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Glucoraphanin is a glucosinolate found in broccoli and cauliflower, in particular in the young sprouts. When these foods are consumed, the enzyme myrosinase transforms glucoraphanin into raphanin, which is an antibiotic, and into sulforaphane, which exhibits anti-cancer and antimicrobial properties in experimental models. Preliminary research also suggests that glucoraphanin may slow and prevent arthritis, and 'retune' mitochondrial metabolism. A variety of broccoli has been bred to reliably contain 2-3 times more glucoraphanin than standard broccoli. Consumption of large amounts of glucoraphanin may produce negative effects due to increased creation of reactive oxygen species. However, this is based on studies on rats fed pure glucoraphanin at a dose equivalent to a human consuming approximately 250 portions of broccoli per day. Other studies have shown glucoraphanin to be safe, even at doses far higher than would be obtained through eating broccoli.
- James, D.; Devaraj, S.; Bellur, P.; Lakkanna, S.; Vicini, J.; Boddupalli, S. (2012). "Novel concepts of broccoli sulforaphanes and disease: Induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli". Nutrition Reviews 70 (11): 654. doi:10.1111/j.1753-4887.2012.00532.x. PMID 23110644.
- Jeffery, E. H.; Brown, A. F.; Kurilich, A. C.; Keck, A. S.; Matusheski, N.; Klein, B. P.; Juvik, J. A. (2003). "Variation in content of bioactive components in broccoli". Journal of Food Composition and Analysis 16 (3): 323–330. doi:10.1016/S0889-1575(03)00045-0.
- Roberts, Michelle (27 August 2013). "Broccoli slows arthritis, researchers think". BBC News. Retrieved 28 August 2013.
- Armah, CN; Traka, MH; Dainty, JR; Defernez, M; Janssens, A; Leung, W; Doleman, JF; Potter, JF; Mithen, RF (Sep 2013). "A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function". The American journal of clinical nutrition 98 (3): 712–22. doi:10.3945/ajcn.113.065235. PMC 3743733. PMID 23964055. Retrieved 3 June 2014.
- Cheng, Maria (October 26, 2011). "UK scientists grow super broccoli". Associated Press. Retrieved 10 November 2011.
- "Beneforte, Super Broccoli". Institute of Food Research, Norwich Research Park, Colney, Norwich, UK. 2014. Retrieved 29 September 2014.
- Perocco P, Bronzetti G, Canistro D, Valgimigli L, Sapone A, Affatato A, Pedulli GF, Pozzetti L, Broccoli M, Iori R, Barillari J, Sblendorio V, Legator MS, Paolini M, Abdel-Rahman SZ.; Bronzetti; Canistro; Valgimigli; Sapone; Affatato; Pedulli; Pozzetti; Broccoli; Iori; Barillari; Sblendorio; Legator; Paolini; Abdel-Rahman (2006). "Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver". Mutation Research 595 (1–2): 125–136. doi:10.1016/j.mrfmmm.2005.11.007. PMID 16442570.
- Lai, RH; Keck, AS; Wallig, MA; West, LG; Jeffery, EH (Jan 2008). "Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin.". Food and Chemical Toxicology 46 (1): 195–202. doi:10.1016/j.fct.2007.07.015. PMID 17804139. Retrieved 3 June 2014.