Glucuronolactone reductase

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glucuronolactone reductase
Identifiers
EC number1.1.1.20
CAS number9028-30-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glucuronolactone reductase (EC 1.1.1.20) is an enzyme that catalyzes the chemical reaction

L-gulono-1,4-lactone + NADP+ D-glucurono-3,6-lactone + NADPH + H+

Thus, the two substrates of this enzyme are L-gulono-1,4-lactone and NADP+, whereas its 3 products are D-glucurono-3,6-lactone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-gulono-1,4-lactone:NADP+ 1-oxidoreductase. Other names in common use include GRase, and gulonolactone dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

References[edit]

  • Suzuki K, Mano Y, Shimazono N (1960). "Conversion of L-gulonolactone to L-ascorbic acid; properties of the microsomal enzyme in rat liver". J. Biochem. 48 (2): 313–315. ISSN 0021-924X.