Jump to content

Glutamine—fructose-6-phosphate transaminase (isomerizing)

From Wikipedia, the free encyclopedia
glutamine-fructose-6-phosphate transaminase (isomerizing)
Glutamine—fructose-6-phosphate transaminase 1, homodimer, Human
EC no.
CAS no.9030-45-9
Alt. names
  • hexosephosphate aminotransferase
  • glucosamine-6-phosphate isomerase (glutamine-forming)
  • glutamine-fructose-6-phosphate transaminase (isomerizing)
  • D-fructose-6-phosphate amidotransferase
  • glucosaminephosphate isomerase
  • glucosamine 6-phosphate synthase
  • GlcN6P synthase
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) (EC is an enzyme that catalyzes the chemical reaction

L-glutamine + D-fructose 6-phosphate L-glutamate + D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). This enzyme participates in glutamate metabolism and aminosugars metabolism.

Structural studies[edit]

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1JXA, 1MOQ, 1MOR, 1MOS, 1XFF, 1XFG, 2BPL, 2J6H, 2POC, 2PUT, 2PUV, and 2PUW.


  • Ghosh S, Blumenthal HJ, Davidson E, Roseman S (1960). "Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate". J. Biol. Chem. 235: 1265–73. PMID 13827775.
  • Gryder RM, Pogell BM (1960). "Further studies on glucosamine 6-phosphate synthesis by rat liver enzymes". J. Biol. Chem. 235: 558–62. PMID 13829889.
  • Leloir LF, Cardini CE (1953). "The biosynthesis of glucosamine". Biochim. Biophys. Acta. 12 (1–2): 15–22. doi:10.1016/0006-3002(53)90119-X. hdl:11336/140740. PMID 13115409.
  • Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B (1999). "The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase". Protein Sci. 8 (3): 596–602. doi:10.1110/ps.8.3.596. PMC 2144271. PMID 10091662.