Glutamine—phenylpyruvate transaminase

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glutamine-phenylpyruvate transaminase
Identifiers
EC number 2.6.1.64
CAS number 68518-06-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a glutamine-phenylpyruvate transaminase (EC 2.6.1.64) is an enzyme that catalyzes the chemical reaction

L-glutamine + phenylpyruvate 2-oxoglutaramate + L-phenylalanine

Thus, the two substrates of this enzyme are L-glutamine and phenylpyruvate, whereas its two products are 2-oxoglutaramate and L-phenylalanine.

This enzyme belongs to the family of transferases, to be specific, the transaminases, that transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:phenylpyruvate aminotransferase. Other names in common use include glutamine transaminase K, and glutamine-phenylpyruvate aminotransferase. It employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1YIY and 1YIZ.

References[edit]

  • Cooper AJ (1978). "Purification of soluble and mitochondrial glutamine transaminase K from rat kidney. Use of a sensitive assay involving transamination between L-phenylalanine and alpha-keto-gamma-methiolbutyrate". Anal. Biochem. 89 (2): 451–60. PMID 727444. doi:10.1016/0003-2697(78)90374-3. 
  • Cooper AJ, Meister A (1974). "Isolation and properties of a new glutamine transaminase from rat kidney". J. Biol. Chem. 249 (8): 2554–61. PMID 4822504.