Glutamine—fructose-6-phosphate transaminase (isomerizing)

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glutamine-fructose-6-phosphate transaminase (isomerizing)
Identifiers
EC number 2.6.1.16
CAS number 9030-45-9
Alt. names
  • hexosephosphate aminotransferase
  • glucosamine-6-phosphate isomerase (glutamine-forming)
  • glutamine-fructose-6-phosphate transaminase (isomerizing)
  • D-fructose-6-phosphate amidotransferase
  • glucosaminephosphate isomerase
  • glucosamine 6-phosphate synthase
  • GlcN6P synthase
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) is an enzyme that catalyzes the chemical reaction

L-glutamine + D-fructose 6-phosphate L-glutamate + D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). This enzyme participates in glutamate metabolism and aminosugars metabolism.

Structural studies[edit]

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1JXA, 1MOQ, 1MOR, 1MOS, 1XFF, 1XFG, 2BPL, 2J6H, 2POC, 2PUT, 2PUV, and 2PUW.

References[edit]