Glutaminyl-peptide cyclotransferase

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glutaminyl-peptide cyclotransferase
Identifiers
EC number 2.3.2.5
CAS number 37257-21-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a glutaminyl-peptide cyclotransferase (EC 2.3.2.5) is an enzyme that catalyzes the chemical reaction

L-glutaminyl-peptide 5-oxoprolyl-peptide + NH3 or
L-glutamyl-peptide 5-oxoprolyl-peptide + H2O

Hence, this enzyme has one substrate, L-glutaminyl-peptide or L-glutamyl-peptide, and two products, 5-oxoprolyl-peptide and NH3 or H2O. The N-terminal 5-oxoproline residue on the peptide is also commonly known as pyroglutamic acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing). Other names in common use include glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, and glutaminyl-transfer ribonucleate cyclotransferase.

Structural studies[edit]

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 2AFM, 2AFO, 2AFS, 2AFU, 2AFW, 2AFX, 2AFZ, and 2IWA.

References[edit]