Glutamyl-tRNA reductase

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glutamyl-tRNA reductase
EC no.
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

A glutamyl-tRNA reductase (EC is an enzyme that catalyzes the chemical reaction

L-glutamate 1-semialdehyde + NADP+ + tRNAGlu L-glutamyl-tRNAGlu + NADPH + H+

The 3 substrates of this enzyme are L-glutamate 1-semialdehyde, NADP+, and tRNA(Glu), whereas its 3 products are L-glutamyl-tRNA(Glu), NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming). This enzyme participates in porphyrin and chlorophyll metabolism.


  • Von Wettstein D, Gough S, Kannangara CG (1995). "Chlorophyll Biosynthesis". Plant Cell. 7 (7): 1039–1057. doi:10.1105/tpc.7.7.1039. PMC 160907. PMID 12242396.
  • Pontoppidan B, Kannangara CG (1994). "Purification and partial characterisation of barley glutamyl-tRNA(Glu) reductase, the enzyme that directs glutamate to chlorophyll biosynthesis". Eur. J. Biochem. 225 (2): 529–37. doi:10.1111/j.1432-1033.1994.00529.x. PMID 7957167.
  • Heinz DW, Inokuchi H, Soll D, Jahn D (2002). "Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate". J. Biol. Chem. 277 (50): 48657–63. doi:10.1074/jbc.M206924200. PMID 12370189.