Glutamyl endopeptidase II

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Glutamyl endopeptidase II
EC number
CAS number 137010-42-5
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glutamyl endopeptidase II (EC, GluSGP) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Preferential cleavage: -Glu- >> -Asp- . Preference for Pro or Leu at P2 and Phe at P3. Cleavage of -Glu-Asp- and -Glu-Pro- bonds is slow

This enzyme is isolated from Streptomyces griseus.


  1. ^ Yoshida, N.; Tsuruyama, S.; Nagata, K.; Hirayama, K.; Noda, K.; Makisumi, S. (1988). "Purification and characterization of an acidic amino acid specific endopeptidase of Streptomyces griseus obtained from a commercial preparation (Pronase)". J. Biochem. (Tokyo). 104: 451–456. PMID 3149277. 
  2. ^ Komiyama, T.; Bigler, T.L.; Yoshida, N.; Noda, K.; Laskowski, M. Jr. (1991). "Replacement of P1 Leu18 by Glu18 in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus Proteinase (GluSGP)". J. Biol. Chem. 266: 10727–10730. PMID 1674942. 
  3. ^ Nagata, K.; Yoshida, N.; Ogata, F.; Araki, M.; Noda, K. (1991). "Subsite mapping of an acidic amino acid-specific endopeptidase from Streptomyces griseus, GluSGP, and protease V8". J. Biochem. (Tokyo). 110: 859–862. PMID 1794975. 
  4. ^ Svendsen, I.; Jensen, M.R.; Breddam, K. (1991). "The primary structure of the glutamic acid-specific protease of Streptomyces griseus". FEBS Lett. 292: 165–167. PMID 1959600. doi:10.1016/0014-5793(91)80859-2. 
  5. ^ Breddam, K.; Meldal, M. (1992). "Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching". Eur. J. Biochem. 206: 103–107. PMID 1587264. doi:10.1111/j.1432-1033.1992.tb16906.x. 

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