Glutathione S-transferase Mu 1

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GSTM1
Protein GSTM1 PDB 1gtu.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1, glutathione S-transferase mu 1
External IDsMGI: 95861 HomoloGene: 121492 GeneCards: GSTM1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GSTM1
Genomic location for GSTM1
Band1p13.3Start109,687,814 bp[1]
End109,709,039 bp[1]
RNA expression pattern
PBB GE GSTM1 204418 x at fs.png

PBB GE GSTM1 215333 x at fs.png

PBB GE GSTM1 204550 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000561
NM_146421

NM_008183

RefSeq (protein)

NP_000552
NP_666533

NP_032209

Location (UCSC)Chr 1: 109.69 – 109.71 MbChr 3: 107.98 – 107.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human Glutathione S-transferase.

Function[edit]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione.

The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3, and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins, as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134184 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040562 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: GSTM1 glutathione S-transferase M1".

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione S-transferase Mu 1