In enzymology, a glutathione oxidase (EC 22.214.171.124) is an enzyme that catalyzes the chemical reaction
- 2 glutathione + O2 glutathione disulfide + H2O2
Thus, the two substrates of this enzyme are glutathione and O2, whereas its two products are glutathione disulfide and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with oxygen as acceptor. The systematic name of this enzyme class is glutathione:oxygen oxidoreductase. This enzyme participates in glutathione metabolism. It employs one cofactor, FAD.
- Kusakabe H, Kuninaka A, Yoshino H (1982). "Purification and properties of a new enzyme, glutathione oxidase from Penicillium sp.K-6-5". Agric. Biol. Chem. 46: 2057–2067. doi:10.1271/bbb1961.46.2057.