Glycerophosphocholine phosphodiesterase

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glycerophosphocholine phosphodiesterase
EC no.
CAS no.9025-85-8
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glycerophosphocholine phosphodiesterase (EC is an enzyme that catalyzes the chemical reaction

sn-glycero-3-phosphocholine + H2O choline + sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are sn-glycero-3-phosphocholine and H2O, whereas its two products are choline and sn-glycerol 3-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is sn-glycero-3-phosphocholine glycerophosphohydrolase. Other names in common use include glycerophosphinicocholine diesterase, glycerylphosphorylcholinediesterase, sn-glycero-3-phosphorylcholine diesterase, glycerolphosphorylcholine phosphodiesterase, and glycerophosphohydrolase. This enzyme participates in glycerophospholipid metabolism.


  • Dawson RMC (1956). "Liver glycerylphosphorylcholine diesterase". Biochem. J. 62: 689–693.
  • Hayaishi O, Kornberg A (1954). "Metabolism of phospholipides by bacterial enzymes". J. Biol. Chem. 206 (2): 647–63. PMID 13143024.
  • Webster GR, Marples EA, Thompson RH (1957). "Glycerylphosphorylcholine diesterase activity in nervous tissue". Biochem. J. 65 (2): 374–377. PMC 1199879. PMID 13403918.