Trifunctional purine biosynthetic protein adenosine-3

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GART
PDB 1rbm EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GART, AIRS, GARS, GARTF, PAIS, PGFT, PRGS, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
External IDs OMIM: 138440 MGI: 95654 HomoloGene: 637 GeneCards: GART
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000819
NM_001136005
NM_001136006
NM_175085

NM_010256

RefSeq (protein)

NP_000810
NP_001129477
NP_001129478
NP_780294

NP_034386

Location (UCSC) n/a Chr 16: 91.62 – 91.65 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Trifunctional purine biosynthetic protein adenosine-3 is an enzyme that in humans is encoded by the GART gene.[3]

This protein is a trifunctional polypeptide. It has Phosphoribosylamine—glycine ligase (EC 6.3.4.13), Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), AIR synthetase (FGAM cyclase) (EC 6.3.3.1) activity which is required for de novo purine biosynthesis.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gnirke A, Barnes TS, Patterson D, Schild D, Featherstone T, Olson MV (July 1991). "Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes". EMBO J. 10 (7): 1629–34. PMC 452831Freely accessible. PMID 2050105. 

Further reading[edit]

External links[edit]