Glycine reductase

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glycine reductase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a glycine reductase (EC is an enzyme that catalyzes the chemical reaction

acetyl phosphate + NH3 + thioredoxin disulfide + H2O glycine + phosphate + thioredoxin

The 4 substrates of this enzyme are acetyl phosphate, NH3, thioredoxin disulfide, and H2O, whereas its 3 products are glycine, phosphate, and thioredoxin.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on X-H and Y-H to form an X-Y bond with a disulfide as acceptor. The systematic name of this enzyme class is acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming).


  • Andreesen JR; Sonntag, D; Grimm, R; Pich, A; Eckerskorn, C; Söhling, B; Andreesen, JR (1999). "Substrate-specific selenoprotein B of glycine reductase from Eubacterium acidaminophilum. Biochemical and molecular analysis". Eur. J. Biochem. 260 (1): 38–49. doi:10.1046/j.1432-1327.1999.00107.x. PMID 10091582. 
  • Bednarski B, Andreesen JR, Pich A (2001). "In vitro processing of the proproteins GrdE of protein B of glycine reductase and PrdA of D-proline reductase from Clostridium sticklandii: formation of a pyruvoyl group from a cysteine residue". Eur. J. Biochem. 268 (12): 3538–44. doi:10.1046/j.1432-1327.2001.02257.x. PMID 11422384.