Glycine transporter 2

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Solute carrier family 6 (neurotransmitter transporter), member 5
Symbols SLC6A5 ; GLYT-2; GLYT2; HKPX3; NET1
External IDs OMIM604159 MGI105090 HomoloGene37901 ChEMBL: 3060 GeneCards: SLC6A5 Gene
RNA expression pattern
PBB GE SLC6A5 210810 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9152 104245
Ensembl ENSG00000165970 ENSMUSG00000039728
UniProt Q9Y345 Q761V0
RefSeq (mRNA) NM_004211 NM_001146013
RefSeq (protein) NP_004202 NP_001139485
Location (UCSC) Chr 11:
20.6 – 20.66 Mb
Chr 7:
49.91 – 49.96 Mb
PubMed search [1] [2]

Glycine transporter 2 (GlyT2) also known as the sodium- and chloride-dependent glycine transporter 2 or solute carrier family 6 member 5 is a protein that in humans is encoded by the SLC6A5 gene.[1]

The glycine transporter 2 is a membrane protein which recaptures glycine, a major inhibitory transmitter in the spinal cord and brainstem. GlyT2 is a specific marker of glycinergic neurons and a member of the Na+ and Cl-coupled transporter family SLC6. Glycine uptake mediated by GlyT2 is electrogenic, coupled to three Na+ and one Cl (i.e. two positive charges per glycine). In humans, GlyT2 is encoded by the SLC6A5 gene. Inactivation of GlyT2 in knockout mice is lethal during the second post-natal week as the absence of GlyT2 disrupts inhibitory transmission by reducing glycine release. Mutations in SLC6A5 gene are responsible for a presynaptic form of hyperekplexia, a genetic disease causing increased startle reflex. GlyT2 main physiological role is to recapture glycine released in the synaptic cleft and to maintain high glycine concentration in the presynaptic neuron. Therefore chronic inhibition of GlyT2 will deplete intracellular storage of glycine and limit its accumulation in synaptic vesicles.[1][2]

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  1. ^ a b Morrow JA, Collie IT, Dunbar DR, Walker GB, Shahid M, Hill DR (November 1998). "Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome". FEBS Lett. 439 (3): 334–40. doi:10.1016/S0014-5793(98)01390-8. PMID 9845349. 
  2. ^ "Entrez Gene: SLC6A5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5". 

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