Glycoside hydrolase family 10
|Glycoside hydrolase, family 10|
crystal structure of the catalytic domain of xylanase a from streptomyces halstedii jm8
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
Glycoside hydrolase family 10 CAZY GH_10 comprises enzymes with a number of known activities; xylanase (EC 18.104.22.168); endo-1,3-beta-xylanase (EC 22.214.171.124); cellobiohydrolase (EC 126.96.36.199). These enzymes were formerly known as cellulase family F.
The microbial degradation of cellulose and xylans requires several types of enzymes such as endoglucanases (EC 188.8.131.52), cellobiohydrolases (EC 184.108.40.206) (exoglucanases), or xylanases (EC 220.127.116.11). Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase family F or as the glycosyl hydrolases family 10.
- Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC . PMID 7624375.
- Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
- Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
- CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
- Beguin P (1990). "Molecular biology of cellulose degradation". Annu. Rev. Microbiol. 44: 219–48. doi:10.1146/annurev.mi.44.100190.001251. PMID 2252383.
- Gilkes NR, Henrissat B, Kilburn DG, Miller RC, Warren RA (June 1991). "Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families". Microbiol. Rev. 55 (2): 303–15. PMC . PMID 1886523.
- Henrissat B, Claeyssens M, Tomme P, Lemesle L, Mornon JP (September 1989). "Cellulase families revealed by hydrophobic cluster analysis". Gene. 81 (1): 83–95. doi:10.1016/0378-1119(89)90339-9. PMID 2806912.
- Henrissat B (December 1991). "A classification of glycosyl hydrolases based on amino acid sequence similarities". Biochem. J. 280 (2): 309–16. doi:10.1042/bj2800309. PMC . PMID 1747104.