|Pronunciation||/ -/,, //|
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||169.073 g·mol−1|
|Appearance||white crystalline powder|
|Density||1.704 (20 °C)|
|Melting point||184.5 °C (364.1 °F; 457.6 K)|
|Boiling point||187 °C (369 °F; 460 K) decomposes|
|1.01 g/100 mL (20 °C)|
|Acidity (pKa)||<2, 2.6, 5.6, 10.6|
|Safety data sheet||InChem MSDS|
|GHS Signal word||Danger|
|P273, P280, P305+351+338, P310, P501|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Glyphosate (IUPAC name: N-(phosphonomethyl)glycine) is a broad-spectrum systemic herbicide and crop desiccant. It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase. It is used to kill weeds, especially annual broadleaf weeds and grasses that compete with crops. It was discovered to be an herbicide by Monsanto chemist John E. Franz in 1970. Monsanto brought it to market for agricultural use in 1974 under the trade name Roundup. Monsanto's last commercially relevant United States patent expired in 2000.
Farmers quickly adopted glyphosate for agricultural weed control, especially after Monsanto introduced glyphosate-resistant Roundup Ready crops, enabling farmers to kill weeds without killing their crops. In 2007, glyphosate was the most used herbicide in the United States' agricultural sector and the second-most used (after 2,4-D) in home and garden, government and industry, and commercial applications. From the late 1970s to 2016, there was a 100-fold increase in the frequency and volume of application of glyphosate-based herbicides (GBHs) worldwide, with further increases expected in the future. This was partly in response to the global emergence and spread of glyphosate-resistant weeds,:1 requiring greater application to maintain effectiveness. The development of glyphosate resistance in weed species is emerging as a costly problem.
Glyphosate is absorbed through foliage, and minimally through roots, and transported to growing points. It inhibits a plant enzyme involved in the synthesis of three aromatic amino acids: tyrosine, tryptophan, and phenylalanine. It is therefore effective only on actively growing plants and is not effective as a pre-emergence herbicide. An increasing number of crops have been genetically engineered to be tolerant of glyphosate (e.g. Roundup Ready soybean, the first Roundup Ready crop, also created by Monsanto), which allows farmers to use glyphosate as a post-emergence herbicide against weeds.
While glyphosate and formulations such as Roundup have been approved by regulatory bodies worldwide, concerns about their effects on humans and the environment persist, and have grown as the global usage of glyphosate increases. A number of regulatory and scholarly reviews have evaluated the relative toxicity of glyphosate as an herbicide. The German Federal Institute for Risk Assessment toxicology review in 2013 found that "the available data is contradictory and far from being convincing" with regard to correlations between exposure to glyphosate formulations and risk of various cancers, including non-Hodgkin lymphoma (NHL). A meta-analysis published in 2014 identified an increased risk of NHL in workers exposed to glyphosate formulations.
In March 2015, the World Health Organization's International Agency for Research on Cancer (IARC) classified glyphosate as "probably carcinogenic in humans" (category 2A) based on epidemiological studies, animal studies, and in vitro studies. In contrast, the European Food Safety Authority concluded in November 2015 that "the substance is unlikely to be genotoxic (i.e. damaging to DNA) or to pose a carcinogenic threat to humans", later clarifying that while carcinogenic glyphosate-containing formulations may exist, studies "that look solely at the active substance glyphosate do not show this effect." The WHO and FAO Joint committee on pesticide residues issued a report in 2016 stating the use of glyphosate formulations does not necessarily constitute a health risk, and giving an admissible daily maximum intake limits of 1 milligram per kilogram (1⁄65536 ounce per pound) of body weight per day for chronic toxicity. The European Chemicals Agency (ECHA) classified glyphosate as causing serious eye damage and as toxic to aquatic life, but did not find evidence implicating it as a carcinogen, a mutagen, toxic to reproduction, nor toxic to specific organs.
Glyphosate was first synthesized in 1950 by Swiss chemist Henry Martin, who worked for the Swiss company Cilag. The work was never published.:1 Stauffer Chemical patented the agent as a chemical chelator in 1964 as it binds and removes minerals such as calcium, magnesium, manganese, copper, and zinc.
Somewhat later, glyphosate was independently discovered in the United States at Monsanto in 1970. Monsanto chemists had synthesized about 100 derivatives of aminomethylphosphonic acid as potential water-softening agents. Two were found to have weak herbicidal activity, and John E. Franz, a chemist at Monsanto, was asked to try to make analogs with stronger herbicidal activity. Glyphosate was the third analog he made.:1–2 Franz received the National Medal of Technology of the United States in 1987 and the Perkin Medal for Applied Chemistry in 1990 for his discoveries.
Monsanto developed and patented the use of glyphosate to kill weeds in the early 1970s and first brought it to market in 1974, under the Roundup brandname. While its initial patent expired in 1991, Monsanto retained exclusive rights in the United States until its patent on the isopropylamine salt expired in September 2000.
In 2008, United States Department of Agriculture (USDA) Agricultural Research Service (ARS) scientist Stephen O. Duke and Stephen B. Powles – an Australian weed expert – described glyphosate as a "virtually ideal" herbicide. In 2010 Powles stated: "glyphosate is a one in a 100-year discovery that is as important for reliable global food production as penicillin is for battling disease."
As of April 2017, the Canadian government stated that glyphosate was "the most widely used herbicide in Canada", at which date the product labels were revised to ensure a limit of 20% POEA by weight.[failed verification] Health Canada's Pest Management Regulatory Agency found no risk to humans or the environment at that 20% limit, and that all products registered in Canada at that time were at or below that limit.
Glyphosate is an aminophosphonic analogue of the natural amino acid glycine and, like all amino acids, exists in different ionic states depending on pH. Both the phosphonic acid and carboxylic acid moieties can be ionised and the amine group can be protonated and the substance exists as a series of zwitterions. Glyphosate is soluble in water to 12 g/l at room temperature. The original synthetic approach to glyphosate involved the reaction of phosphorus trichloride with formaldehyde followed by hydrolysis to yield a phosphonate. Glycine is then reacted with this phosphonate to yield glyphosate, and its name is taken as a contraction of the compounds used in this synthesis step, namely glycine and a phosphonate.
- PCl3 + H2CO → Cl2P(=O)−CH2Cl
- Cl2P(=O)−CH2Cl + 2 H2O → (HO)2P(=O)−CH2Cl + 2 HCl
- (HO)2P(=O)−CH2Cl + H2N−CH2−COOH → (HO)2P(=O)−CH2−NH−CH2−COOH + HCl
Two main approaches are used to synthesize glyphosate industrially. The first is to react iminodiacetic acid with phosphorous acid and hydrochloric acid (sometimes formed in situ by addition of phosphorus trichloride) via a modified Mannich reaction. Oxidation then leads to the desired glyphosate product. Iminodiacetic acid is usually prepared on-site by various methods depending on reagent availability.
The second involves hydrophosphonylation, using dimethyl phosphite in a one-pot synthesis. Glycine and paraformaldehyde are reacted in a suitable organic solvent (typically triethylamine and methanol) to produce bishydroxymethylglycine, (HOCH2)2NCH2COOH. Dimethyl phosphite is then introduced, which leads to a substitution reaction of the hydroxyl of one of the two hydroxymethyl groups. Work-up with hydrochloric acid and heat cleaves the remaining hydroxymethyl group from the nitrogen atom and hydrolyzes both phosphate ester linkages.
This synthetic approach is responsible for a substantial portion of the production of glyphosate in China, with considerable work having gone into recycling the triethylamine and methanol. Progress has also been made in attempting to eliminate the need for triethylamine altogether.
Technical grade glyphosate is a white powder which, according to FAO specification, should contain not less than 95% glyphosate. Formaldehyde, classified as a known human carcinogen,   and N-nitrosoglyphosate, have been identified as toxicologically relevant impurities. The FAO specification limits the formaldehyde concentration to a maximum of 1.3 g/kg glyphosate. N-Nitrosoglyphosate, "belonging to a group of impurities of particular concern as they can be activated to genotoxic carcinogens", should not exceed 1 ppm.
Glyphosate is marketed in the United States and worldwide by many agrochemical companies, in different solution strengths and with various adjuvants, under dozens of tradenames. As of 2010, more than 750 glyphosate products were on the market. In 2012, about half of the total global consumption of glyphosate by volume was for agricultural crops, with forestry comprising another important market. Asia and the Pacific was the largest and fastest growing regional market. As of 2014, Chinese manufacturers collectively are the world's largest producers of glyphosate and its precursors and account for about 30% of global exports. Key manufacturers include Anhui Huaxing Chemical Industry Company, BASF, Bayer CropScience (which also acquired the maker of glyphosate, Monsanto), Dow AgroSciences, DuPont, Jiangsu Good Harvest-Weien Agrochemical Company, Nantong Jiangshan Agrochemical & Chemicals Co., Nufarm, SinoHarvest, Syngenta, and Zhejiang Xinan Chemical Industrial Group Company.
Glyphosate is an acid molecule, so it is formulated as a salt for packaging and handling. Various salt formulations include isopropylamine, diammonium, monoammonium, or potassium as the counterion. The active ingredient of the Monsanto herbicides is the isopropylamine salt of glyphosate. Another important ingredient in some formulations is the surfactant polyethoxylated tallow amine (POEA). Some brands include more than one salt. Some companies report their product as acid equivalent (ae) of glyphosate acid, or some report it as active ingredient (ai) of glyphosate plus the salt, and others report both. To compare performance of different formulations, knowledge of how the products were formulated is needed. Given that different salts have different weights, the acid equivalent is a more accurate method of expressing and comparing concentrations.
Adjuvant loading refers to the amount of adjuvant already added to the glyphosate product. Fully loaded products contain all the necessary adjuvants, including surfactant; some contain no adjuvant system, while other products contain only a limited amount of adjuvant (minimal or partial loading) and additional surfactants must be added to the spray tank before application.
Products are supplied most commonly in formulations of 120, 240, 360, 480, and 680 g/l of active ingredient. The most common formulation in agriculture is 360 g/l, either alone or with added cationic surfactants.
For 360 g/l formulations, European regulations allow applications of up to 12 l/ha for control of perennial weeds such as couch grass. More commonly, rates of 3 l/ha are practiced for control of annual weeds between crops.
Mode of action
Glyphosate interferes with the shikimate pathway, which produces the aromatic amino acids phenylalanine, tyrosine and tryptophan in plants and microorganisms – but does not exist in the genome of mammals, including humans. It blocks this pathway by inhibiting the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which catalyzes the reaction of shikimate-3-phosphate (S3P) and phosphoenolpyruvate to form 5-enolpyruvyl-shikimate-3-phosphate (EPSP). Glyphosate is absorbed through foliage and minimally through roots, meaning that it is only effective on actively growing plants and cannot prevent seeds from germinating. After application, glyphosate is readily transported around the plant to growing roots and leaves and this systemic activity is important for its effectiveness. Inhibiting the enzyme causes shikimate to accumulate in plant tissues and diverts energy and resources away from other processes, eventually killing the plant. While growth stops within hours of application, it takes several days for the leaves to begin turning yellow.
Under normal circumstances, EPSP is dephosphorylated to chorismate, an essential precursor for the amino acids mentioned above. These amino acids are used in protein synthesis and to produce secondary metabolites such as folates, ubiquinones, and naphthoquinone.
X-ray crystallographic studies of glyphosate and EPSPS show that glyphosate functions by occupying the binding site of the phosphoenolpyruvate, mimicking an intermediate state of the ternary enzyme–substrate complex. Glyphosate inhibits the EPSPS enzymes of different species of plants and microbes at different rates.
Glyphosate is effective in killing a wide variety of plants, including grasses and broadleaf and woody plants. By volume, it is one of the most widely used herbicides. In 2007, glyphosate was the most used herbicide in the United States agricultural sector, with 180 to 185 million pounds (82,000 to 84,000 tonnes) applied, the second-most used in home and garden with 5 to 8 million pounds (2,300 to 3,600 tonnes) and [clarification needed] 13 to 15 million pounds (5,900 to 6,800 tonnes) in industry and commerce. It is commonly used for agriculture, horticulture, viticulture, and silviculture purposes, as well as garden maintenance (including home use). It has a relatively small effect on some clover species and morning glory.
Glyphosate and related herbicides are often used in invasive species eradication and habitat restoration, especially to enhance native plant establishment in prairie ecosystems. The controlled application is usually combined with a selective herbicide and traditional methods of weed eradication such as mulching to achieve an optimal effect.
In many cities, glyphosate is sprayed along the sidewalks and streets, as well as crevices in between pavement where weeds often grow. However, up to 24% of glyphosate applied to hard surfaces can be run off by water. Glyphosate contamination of surface water is attributed to urban and agricultural use. Glyphosate is used to clear railroad tracks and get rid of unwanted aquatic vegetation. Since 1994, glyphosate has been used in aerial spraying in Colombia in coca eradication programs; Colombia announced in May 2015 that by October, it would cease using glyphosate in these programs due to concerns about human toxicity of the chemical.
Glyphosate is also used for crop desiccation (siccation) to increase harvest yield and uniformity. Glyphosate itself is not a chemical desiccant; rather glyphosate application just before harvest kills the crop plants so that the food crop dries from environmental conditions ("dry-down") more quickly and evenly. Because glyphosate is systemic, excess residue levels can persist in plants due to incorrect application and this may render the crop unfit for sale. When applied appropriately, it can promote useful effects. In sugarcane, for example, glyphosate application increases sucrose concentration before harvest. In grain crops (wheat, barley, oats), uniformly dried crops do not have to be windrowed (swathed and dried) prior to harvest, but can easily be straight-cut and harvested. This saves the farmer time and money, which is important in northern regions where the growing season is short, and it enhances grain storage when the grain has a lower and more uniform moisture content.
Genetically modified crops
Some micro-organisms have a version of 5-enolpyruvoyl-shikimate-3-phosphate synthetase (EPSPS) resistant to glyphosate inhibition. A version of the enzyme that was both resistant to glyphosate and that was still efficient enough to drive adequate plant growth was identified by Monsanto scientists after much trial and error in an Agrobacterium strain called CP4, which was found surviving in a waste-fed column at a glyphosate production facility.:56 This CP4 EPSPS gene was cloned and transfected into soybeans. In 1996, genetically modified soybeans were made commercially available. Current glyphosate-resistant crops include soy, maize (corn), canola, alfalfa, sugar beets, and cotton, with wheat still under development.
In 2015, 89% of corn, 94% of soybeans, and 89% of cotton produced in the United States were from strains that were genetically modified to be herbicide-tolerant - including but not limited to glyphosate.
Glyphosate strongly sorbs onto soil minerals, and, exception made of colloid-facilitated transport, its soluble residues are expected to be poorly mobile in the free porewater of soils. The spatial extent of ground and surface water pollution is therefore considered to be relatively limited. Glyphosate is readily degraded by soil microbes to aminomethylphosphonic acid (AMPA, which like glyphosate strongly adsorbs to soil solids and is thus unlikely to leach to groundwater). Though both glyphosate and AMPA are commonly detected in water bodies, a portion of the AMPA detected may actually be the result of degradation of detergents rather than from glyphosate. Glyphosate does have the potential to contaminate surface waters due to its aquatic use patterns and through erosion, as it adsorbs to colloidal soil particles suspended in runoff. Detection in surface waters (particularly downstream from agricultural uses) has been reported as both broad and frequent by USGS researchers, although other similar research found equal frequencies of detection in urban-dominated small streams. Rain events can trigger dissolved glyphosate loss in transport-prone soils. The mechanism of glyphosate sorption to soil is similar to that of phosphate fertilizers, the presence of which can reduce glyphosate sorption. Phosphate fertilizers are subject to release from sediments into water bodies under anaerobic conditions, and similar release can also occur with glyphosate, though significant impact of glyphosate release from sediments has not been established. Limited leaching can occur after high rainfall after application. If glyphosate reaches surface water, it is not broken down readily by water or sunlight.
The half-life of glyphosate in soil ranges between 2 and 197 days; a typical field half-life of 47 days has been suggested. Soil and climate conditions affect glyphosate's persistence in soil. The median half-life of glyphosate in water varies from a few to 91 days. At a site in Texas, half-life was as little as three days. A site in Iowa had a half-life of 141.9 days. The glyphosate metabolite AMPA has been found in Swedish forest soils up to two years after a glyphosate application. In this case, the persistence of AMPA was attributed to the soil being frozen for most of the year. Glyphosate adsorption to soil, and later release from soil, varies depending on the kind of soil. Glyphosate is generally less persistent in water than in soil, with 12- to 60-day persistence observed in Canadian ponds, although persistence of over a year has been recorded in the sediments of American ponds. The half-life of glyphosate in water is between 12 days and 10 weeks.
Residues in food products
According to the National Pesticide Information Center fact sheet, glyphosate is not included in compounds tested for by the Food and Drug Administration's Pesticide Residue Monitoring Program, nor in the United States Department of Agriculture's Pesticide Data Program. However, a field test showed that lettuce, carrots, and barley contained glyphosate residues up to one year after the soil was treated with 3.71 lb of glyphosate per acre (4.15 kg per hectare). The U.S. has determined the acceptable daily intake of glyphosate at 1.75 milligrams per kilogram of bodyweight per day (mg/kg/bw/day) while the European Union has set it at 0.5.
Pesticide residue controls carried out by EU Member States in 2016 analysed 6,761 samples of food products for glyphosate residues. 3.6% of the samples contained quantifiable glyphosate residue levels with 19 samples (0.28%) exceeding the European maximum residue levels (MRLs), which included six samples of honey and other apicultural products (MRL = 0.05 mg/kg) and eleven samples of buckwheat and other pseudo‐cereals (MRL = 0.1 mg/kg). Glyphosate residues below the European MRLs were most frequently found in dry lentils, linseeds, soya beans, dry peas, tea, buckwheat, barley, wheat and rye.
Glyphosate is the active ingredient in herbicide formulations containing it. However, in addition to glyphosate salts, commercial formulations of glyphosate contain additives (known as adjuvants) such as surfactants, which vary in nature and concentration. Surfactants such as polyethoxylated tallow amine (POEA) are added to glyphosate to enable it to wet the leaves and penetrate the cuticle of the plants.
The acute oral toxicity for mammals is low, but death has been reported after deliberate overdose of concentrated formulations. The surfactants in glyphosate formulations can increase the relative acute toxicity of the formulation. In a 2017 risk assessment, the European Chemicals Agency (ECHA) wrote: "There is very limited information on skin irritation in humans. Where skin irritation has been reported, it is unclear whether it is related to glyphosate or co-formulants in glyphosate-containing herbicide formulations." The ECHA concluded that available human data was insufficient to support classification for skin corrosion or irritation. Inhalation is a minor route of exposure, but spray mist may cause oral or nasal discomfort, an unpleasant taste in the mouth, or tingling and irritation in the throat. Eye exposure may lead to mild conjunctivitis. Superficial corneal injury is possible if irrigation is delayed or inadequate.
The consensus among national pesticide regulatory agencies and scientific organizations is that labeled uses of glyphosate have demonstrated no evidence of human carcinogenicity. The Joint FAO/WHO Meeting on Pesticide Residues (JMPR), the European Commission, the Canadian Pest Management Regulatory Agency, the Australian Pesticides and Veterinary Medicines Authority and the German Federal Institute for Risk Assessment have concluded that there is no evidence that glyphosate poses a carcinogenic or genotoxic risk to humans. The EPA has classified glyphosate as "not likely to be carcinogenic to humans." One international scientific organization, the International Agency for Research on Cancer, classified glyphosate in Group 2A, "probably carcinogenic to humans" in 2015.
There is weak evidence human cancer risk might increase as a result of occupational exposure to large amounts of glyphosate, such as agricultural work, but no good evidence of such a risk from home use, such as in domestic gardening. According to a systematic review and meta-analysis published in 2016, when weak statistical associations with cancer have been found, such observations have been attributed to bias and confounding in correlational studies due to workers often being exposed to other known carcinogens. The review reported that studies that show an effect between glyphosate use and non-Hodgkin lymphoma have been criticized for not assessing these factors, underlying quality of studies being reviewed, or whether the relationship is causal rather than only correlational. Writing for the Natural Resources Defense Council environmental advocacy group, Jennifer Sass criticized the influence exerted by Monsanto on research about glyphosate safety, and noted that the review was funded by Monsanto.
A meta-analysis published in 2019 looked at whether there was an association between an increased risk of non-Hodgkin lymphoma in humans and high cumulative exposures to glyphosate-based herbicides. The analysis used the most recent update of the Agricultural Health Study cohort published in 2018 and five case-control studies published in 2019. The research found a "compelling link" between exposures to glyphosate-based herbicides and increased risk for non-Hodgkin lymphoma.
Amongst mammals, glyphosate is considered to have "low to very low toxicity". The LD50 of glyphosate is 5,000 mg/kg for rats, 10,000 mg/kg in mice and 3,530 mg/kg in goats. The acute dermal LD50 in rabbits is greater than 2,000 mg/kg. Indications of glyphosate toxicity in animals typically appear within 30 to 120 minutes following ingestion of a large enough dose, and include initial excitability and tachycardia, ataxia, depression, and bradycardia, although severe toxicity can develop into collapse and convulsions.
A review of unpublished short-term rabbit-feeding studies reported severe toxicity effects at 150 mg/kg/day and "no observed adverse effect level" doses ranging from 50 to 200 mg/kg/day. Glyphosate can have carcinogenic effects in nonhuman mammals. These include the induction of positive trends in the incidence of renal tubule carcinoma and haemangiosarcoma in male mice, and increased pancreatic islet-cell adenoma in male rats. In reproductive toxicity studies performed in rats and rabbits, no adverse maternal or offspring effects were seen at doses below 175–293 mg/kg/day.
Glyphosate-based herbicides may cause life-threatening arrhythmias in mammals. Evidence also shows that such herbicides cause direct electrophysiological changes in the cardiovascular systems of rats and rabbits.
In many freshwater invertebrates, glyphosate has a 48-hour LC50 ranging from 55 to 780 ppm. The 96-hour LC50 is 281 ppm for grass shrimp (Palaemonetas vulgaris) and 934 ppm for fiddler crabs (Uca pagilator). These values make glyphosate "slightly toxic to practically non-toxic".
The antimicrobial activity of glyphosate has been described in the microbiology literature since its discovery in 1970 and the description of glyphosate's mechanism of action in 1972. Efficacy was described for numerous bacteria and fungi. Glyphosate can control the growth of apicomplexan parasites, such as Toxoplasma gondii, Plasmodium falciparum (malaria), and Cryptosporidium parvum, and has been considered an antimicrobial agent in mammals. Inhibition can occur with some Rhizobium species important for soybean nitrogen fixation, especially under moisture stress.
When glyphosate comes into contact with the soil, it can be bound to soil particles, thereby slowing its degradation. Glyphosate and its degradation product, aminomethylphosphonic acid are considered to be much more benign toxicologically and environmentally than most of the herbicides replaced by glyphosate. A 2016 meta-analysis concluded that at typical application rates glyphosate had no effect on soil microbial biomass or respiration. A 2016 review noted that contrasting effects of glyphosate on earthworms have been found in different experiments with some species unaffected, but others losing weight or avoiding treated soil. Further research is required to determine the impact of glyphosate on earthworms in complex ecosystems.
In 2007, the EPA selected glyphosate for further screening through its Endocrine Disruptor Screening Program (EDSP). Selection for this program is based on a compound's prevalence of use and does not imply particular suspicion of endocrine activity. On June 29, 2015, the EPA released Weight of Evidence Conclusion of the EDSP Tier 1 screening for glyphosate, recommending that glyphosate not be considered for Tier 2 testing. The Weight of Evidence conclusion stated "...there was no convincing evidence of potential interaction with the estrogen, androgen or thyroid pathways." A review of the evidence by the European Food Safety Authority published in September 2017 showed conclusions similar to those of the EPA report.
Effect on plant health
Some studies have found causal relationships between glyphosate and increased or decreased disease resistance. Exposure to glyphosate has been shown to change the species composition of endophytic bacteria in plant hosts, which is highly variable.
Glyphosate-based formulations may contain a number of adjuvants, the identities of which may be proprietary. Surfactants are used in herbicide formulations as wetting agents, to maximize coverage and aid penetration of the herbicide(s) through plant leaves. As agricultural spray adjuvants, surfactants may be pre-mixed into commercial formulations or they may be purchased separately and mixed on-site.
Polyethoxylated tallow amine (POEA) is a surfactant used in the original Roundup formulation and was commonly used in 2015. Different versions of Roundup have included different percentages of POEA. A 1997 US government report said that Roundup is 15% POEA while Roundup Pro is 14.5%. Since POEA is more toxic to fish and amphibians than glyphosate alone, POEA is not allowed in aquatic formulations. A 2000 review of the ecotoxicological data on Roundup shows at least 58 studies exist on the effects of Roundup on a range of organisms. This review concluded that "...for terrestrial uses of Roundup minimal acute and chronic risk was predicted for potentially exposed non-target organisms".
Acute toxicity and chronic toxicity are dose-related. Skin exposure to ready-to-use concentrated glyphosate formulations can cause irritation, and photocontact dermatitis has been occasionally reported. These effects are probably due to the preservative benzisothiazolin-3-one. Severe skin burns are very rare. Inhalation is a minor route of exposure, but spray mist may cause oral or nasal discomfort, an unpleasant taste in the mouth, or tingling and irritation in the throat. Eye exposure may lead to mild conjunctivitis. Superficial corneal injury is possible if irrigation is delayed or inadequate. Death has been reported after deliberate overdose. Ingestion of Roundup ranging from 85 to 200 ml (of 41% solution) has resulted in death within hours of ingestion, although it has also been ingested in quantities as large as 500 ml with only mild or moderate symptoms. Adult consumption of more than 85 ml of concentrated product can lead to corrosive esophageal burns and kidney or liver damage. More severe cases cause "respiratory distress, impaired consciousness, pulmonary edema, infiltration on chest X-ray, shock, arrhythmias, renal failure requiring haemodialysis, metabolic acidosis, and hyperkalaemia" and death is often preceded by bradycardia and ventricular arrhythmias. While the surfactants in formulations generally do not increase the toxicity of glyphosate itself, it is likely that they contribute to its acute toxicity.
A 2000 review concluded that "under present and expected conditions of new use, there is no potential for Roundup herbicide to pose a health risk to humans". A 2012 meta-analysis of epidemiological studies (seven cohort studies and fourteen case-control studies) of exposure to glyphosate formulations found no correlation with any kind of cancer. The 2013 systematic review by the German Institute for Risk Assessment of epidemiological studies of workers who use pesticides, exposed to glyphosate formulations found no significant risk, stating that "the available data are contradictory and far from being convincing".:vol. 1, 64–66 However, a 2014 meta-analysis of the same studies found a correlation between occupational exposure to glyphosate formulations and increased risk of B cell lymphoma, the most common kind of non-Hodgkin lymphoma. Workers exposed to glyphosate were about twice as likely to get B cell lymphoma.
A 2016 systematic review and meta-analysis found no causal relationship between glyphosate exposure and risk of any type of lymphohematopoietic cancer including non-Hodgkin lymphoma and multiple myeloma. The same review noted that the positive associations found may be due to bias and confounding. The Natural Resources Defense Council has criticized that review, noting that it was funded by Monsanto.
A 2015 systematic review of 10 observational studies found that except for an excess of attention deficit hyperactivity disorder among children born to glyphosate appliers, there was no evidence that glyphosate exposure among pregnant mothers caused adverse developmental outcomes in their children. Noting the limited size and scope of the review articles available, the authors noted that "these negative findings cannot be taken as definitive evidence that GLY, at current levels of occupational and environmental exposures, brings no risk for human development and reproduction."
Glyphosate products for aquatic use generally do not use surfactants, and aquatic formulations do not use POEA due to aquatic organism toxicity. Due to the presence of POEA, such glyphosate formulations only allowed for terrestrial use are more toxic for amphibians and fish than glyphosate alone. The half-life of POEA (21–42 days) is longer than that for glyphosate (7–14 days) in aquatic environments. Aquatic organism exposure risk to terrestrial formulations with POEA is limited to drift or temporary water pockets where concentrations would be much lower than label rates.
Some researchers have suggested the toxicity effects of pesticides on amphibians may be different from those of other aquatic fauna because of their lifestyle; amphibians may be more susceptible to the toxic effects of pesticides because they often prefer to breed in shallow, lentic, or ephemeral pools. These habitats do not necessarily constitute formal water-bodies and can contain higher concentrations of pesticide compared to larger water-bodies. Studies in a variety of amphibians have shown the toxicity of GBFs containing POEA to amphibian larvae. These effects include interference with gill morphology and mortality from either the loss of osmotic stability or asphyxiation. At sub-lethal concentrations, exposure to POEA or glyphosate/POEA formulations have been associated with delayed development, accelerated development, reduced size at metamorphosis, developmental malformations of the tail, mouth, eye and head, histological indications of intersex and symptoms of oxidative stress. Glyphosate-based formulations can cause oxidative stress in bullfrog tadpoles.
A 2003 study of various formulations of glyphosate found, "[the] risk assessments based on estimated and measured concentrations of glyphosate that would result from its use for the control of undesirable plants in wetlands and over-water situations showed that the risk to aquatic organisms is negligible or small at application rates less than 4 kg/ha and only slightly greater at application rates of 8 kg/ha."
A 2013 meta-analysis reviewed the available data related to potential impacts of glyphosate-based herbicides on amphibians. According to the authors, the use of glyphosate-based pesticides cannot be considered the major cause of amphibian decline, the bulk of which occurred prior to the widespread use of glyphosate or in pristine tropical areas with minimal glyphosate exposure. The authors recommended further study of species- and development-stage chronic toxicity, of environmental glyphosate levels, and ongoing analysis of data relevant to determining what if any role glyphosate might be playing in worldwide amphibian decline, and suggest including amphibians in standardized test batteries.
Several studies have not found mutagenic effects, so glyphosate has not been listed in the United States Environmental Protection Agency or the International Agency for Research on Cancer databases. Various other studies suggest glyphosate may be mutagenic. The IARC monograph noted that glyphosate-based formulations can cause DNA strand breaks in various taxa of animals in vitro.
Government and organization positions
European Food Safety Authority
A 2013 systematic review by the German Institute for Risk Assessment (BfR) examined more than 1000 epidemiological studies, animal studies, and in vitro studies. It found that "no classification and labelling for carcinogenicity is warranted" and did not recommend a carcinogen classification of either 1A or 1B.:34–37, 139 It provided the review to EFSA in January 2014 which published it in December 2014. In November 2015, EFSA published its conclusion in the Renewal Assessment Report (RAR), stating it was "unlikely to pose a carcinogenic hazard to humans". The EU was largely informed by this report when it made its decision on the use of glyphosate in November 2017.
EFSA's decision and the BfR report were criticized in an open letter published by 96 scientists in November 2015 saying that the BfR report failed to adhere to accepted scientific principles of open and transparent procedures. The BfR report included unpublished data, lacked authorship, omitted references, and did not disclose conflict-of-interest information.
In April 2016, Dr. Vytenis Andriukaitis, European Commissioner for Health and Food Safety, wrote an open letter to the Chair of the Board of the Glyphosate Task at Monsanto Europe asking to publish the full studies provided to the EFSA.
In September 2017, The Guardian reported that sections of the Renewal Assessment Report prepared by the BfR and used by Efsa were copy-pasted from a study done by Monsanto. Some sections of copy contained small changes such as using British spelling rather than American forms but others were copied word for word, including most of the peer-reviewed papers that were used in the report. The Guardian reported that a "Monsanto spokesperson said that Efsa allowed renewal reports to be written this way because of the large volume of toxicological studies submitted."
US Environmental Protection Agency
In a 1993 review, the EPA, considered glyphosate to be noncarcinogenic and relatively low in dermal and oral acute toxicity. The EPA considered a "worst case" dietary risk model of an individual eating a lifetime of food derived entirely from glyphosate-sprayed fields with residues at their maximum levels. This model indicated that no adverse health effects would be expected under such conditions. In 2015, the EPA initiated a review of glyphosate's toxicity and in 2016 reported that glyphosate is likely not carcinogenic.
In May 2019, CNN reported that the agency had reaffirmed its position that, when used according to instructions, glyphosate is not carcinogenic. Noting company emails between Monsanto and EPA executives released in 2015 which appear to suggest that an EPA official offered to kill an agency glyphosate review, CNN cited "concerns about whether Monsanto has had undue influence over regulators."
International Agency for Research on Cancer
In March 2015, the International Agency for Research on Cancer (IARC), an intergovernmental agency forming part of the World Health Organization of the United Nations, published a summary of their forthcoming monograph on glyphosate, and classified glyphosate as "probably carcinogenic in humans" (category 2A) based on epidemiological studies, animal studies, and in vitro studies. It noted that there was "limited evidence" of carcinogenicity in humans for non-Hodgkin lymphoma. The IARC classifies substances for their carcinogenic potential, and "a few positive findings can be enough to declare a hazard, even if there are negative studies, as well." Unlike the BfR, it does not conduct a risk assessment, weighing benefits against risk.
The BfR responded that IARC reviewed only a selection of what they had reviewed earlier, and argued that other studies, including a cohort study called Agricultural Health Study, do not support the classification. The IARC report did not include unpublished studies, including one completed by the IARC panel leader. The agency's international protocol dictates that only published studies be used in classifications of carcinogenicity, since national regulatory agencies including the EPA have allowed agrochemical corporations to conduct their own unpublished research, which may be biased in support of their profit motives.
Monsanto response and campaign
Monsanto called the IARC report biased and said it wanted the report to be retracted. In 2017, internal documents from Monsanto were made public by lawyers pursuing litigation against the company, who used the term "Monsanto papers" to describe the documents. This term was later used also by Leemon McHenry and others. The documents indicated Monsanto had planned a public relations effort to discredit the IARC report, and had engaged Henry Miller to write a 2015 opinion piece in Forbes Magazine challenging the report. Miller did not reveal the connection to Forbes, and according to the New York Times, when Monsanto asked him if he was interested in writing such an article, he replied "I would be if I could start from a high-quality draft" provided by the company. Once this became public, Forbes removed his blog from their site.
Two journalists from Le Monde won the 2018 European Press Prize for a series of articles on the documents, also titled Monsanto Papers. Their reporting described, among other things, Monsanto's lawyers' letters demanding that IARC scientists turn over documents relating to Monograph 112, which contained the IARC finding that glyphosate was a "probable carcinogen"; several of the scientists condemned these letters as intimidating.
Reviews of the EFSA and IARC reports
A 2017 review done by personnel from EFSA and BfR argued that the differences between the IARC's and EFSA's conclusions regarding glyphosate and cancer were due to differences in their evaluation of the available evidence. The review concluded that "Two complementary exposure assessments ... suggests that actual exposure levels are below" the reference values identified by the EFSA "and do not represent a public concern."
In contrast, a 2016 analysis concluded that in the EFSA's Renewal Assessment Report, "almost no weight is given to studies from the published literature and there is an over-reliance on non-publicly available industry-provided studies using a limited set of assays that define the minimum data necessary for the marketing of a pesticide", arguing that the IARC's evaluation of probably carcinogenic to humans "accurately reflects the results of published scientific literature on glyphosate".
In October 2017, an article in The Times revealed that Christopher Portier, a scientist advising the IARC in the assessment of glyphosate and advocate for its classification as possibly carcinogenic, had received consulting contracts with two law firm associations representing alleged glyphosate cancer victims that included a payment of US$160,000 to Portier. The IARC final report was also found to have changed compared to an interim report, through the removal of text saying certain studies had found glyphosate was not carcinogenic in that study's context, and through strengthening a conclusion of "limited evidence of animal carcinogenicity," to "sufficient evidence of animal carcinogenicity".
California Office of Environmental Health Hazard Assessment
In March 2015, the California Office of Environmental Health Hazard Assessment (OEHHA) announced plans to have glyphosate listed as a known carcinogen based on the IARC assessment. In 2016, Monsanto started a case against OEHHA and its acting director, Lauren Zeise, but lost the suit in March 2017.
Glyphosate was listed as "known to the State of California to cause cancer" in 2017. In February 2018, as part of an ongoing case, an injunction was issued prohibiting California from enforcing carcinogenicity labeling requirements for glyphosate until the case was resolved. The injunction stated that arguments by California "[do] not change the fact that the overwhelming majority of agencies that that have examined glyphosate have determined it is not a cancer risk.". In August 2019, the EPA also said it no longer allow labels claiming glyphosate is a carcinogen, as those claims would "not meet the labeling requirements of the Federal Insecticide, Fungicide, and Rodenticide Act" and misinform the public.
European Chemicals Agency
On March 15, 2017 the European Chemicals Agency (ECHA) announced recommendations proceeding from a risk assessment of glyphosate performed by ECHA's Committee for Risk Assessment (RAC). Their recommendations maintained the current classification of glyphosate as a substance causing serious eye damage and as a substance toxic to aquatic life. However, the RAC did not find evidence implicating glyphosate to be a carcinogen, a mutagen, toxic to reproduction, nor toxic to specific organs.
Effects of use
Emergence of resistant weeds
In the 1990s, no glyphosate-resistant weeds were known to exist. By 2014, glyphosate-resistant weeds dominated herbicide-resistance research. At that time, 23 glyphosate-resistant species were found in 18 countries. "Resistance evolves after a weed population has been subjected to intense selection pressure in the form of repeated use of a single herbicide."
According to Ian Heap, a weed specialist, who completed his PhD on resistance to multiple herbicides in annual ryegrass (Lolium rigidum) in 1988 – the first case of an herbicide-resistant weed in Australia – by 2014 the Lolium rigidum was the "world’s worst herbicide-resistant weed with instances in "12 countries, 11 sites of action, 9 cropping regimens" and affecting over 2 million hectares. Annual ryegrass was known to be resistant to herbicides since 1982. The first documented case of glyphosate-resistant L. rigidum was reported in Australia in 1996 near Orange, New South Wales. In 2006, farmers associations were reporting 107 biotypes of weeds within 63 weed species with herbicide resistance. In 2009, Canada identified its first resistant weed, giant ragweed, and at that time 15 weed species had been confirmed as resistant to glyphosate. As of 2010, in the United States 7 to 10 million acres (2.8 to 4.0 million hectares) of soil were afflicted by herbicide-resistant weeds, or about 5% of the 170 million acres planted with corn, soybeans, and cotton, the crops most affected, in 22 states. In 2012, Charles Benbrook reported that the Weed Science Society of America listed 22 herbicide-resistant in the U.S., with over 5.7×106 ha (14×106 acres) infested by GR weeds and that Dow AgroSciences had carried out a survey and reported a figure of around 40×106 ha (100×106 acres). The International Survey of Herbicide Resistant Weeds database lists species that are resistant to glyphosate.
In response to resistant weeds, farmers are hand-weeding, using tractors to turn over soil between crops, and using other herbicides in addition to glyphosate.
In 2004, a glyphosate-resistant variation of Palmer amaranth was found in the U.S. state of Georgia and confirmed by a 2005 study. In 2005, resistance was also found in North Carolina. The species can quickly become resistant to multiple herbicides and has developed multiple mechanisms for glyphosate resistance due to selection pressure. The glyphosate-resistant weed variant is now widespread in the southeastern United States. Cases have also been reported in Texas and Virginia.
Conyza bonariensis (also known as hairy fleabane and buva) and Conyza canadensis (known as horseweed or marestail) are other weed species that have lately developed glyphosate resistance. A 2008 study on the current situation of glyphosate resistance in South America concluded "resistance evolution followed intense glyphosate use" and the use of glyphosate-resistant soybean crops is a factor encouraging increases in glyphosate use. In the 2015 growing season, glyphosate-resistant marestail proved to be especially problematic to control in Nebraska production fields.
Glyphosate-resistant ryegrass (Lolium) has occurred in most of the Australian agricultural areas and other areas of the world. All cases of evolution of resistance to glyphosate in Australia were characterized by intensive use of the herbicide while no other effective weed control practices were used. Studies indicate the resistant ryegrass does not compete well against nonresistant plants and their numbers decrease when not grown under conditions of glyphosate application.
Monarch butterfly populations
Use of 2-4 D and other herbicides like glyphosate to clear milkweed along roads and fields may have contributed to a decline in monarch butterfly populations in the Midwestern United States. Along with deforestation and adverse weather conditions, the decrease in milkweed contributed to an 81% decline in monarchs. The Natural Resources Defense Council (NRDC) filed a suit against the EPA in 2015, in which it argued that the agency ignored warnings about the potentially dangerous impacts of glyphosate usage on monarchs.
Glyphosate was first approved for use in the 1970s, and as of 2010 was labelled for use in 130 countries.:2
In 2017 Vandenberg et al. cited a 100-fold increase in the use of glyphosate-based herbicides from 1974 to 2014, the possibility that herbicide mixtures likely have effects that are not predicted by studying glyphosate alone, and reliance of current safety assessments on studies done over 30 years ago. They recommended that current safety standards be updated, writing that the current standards "may fail to protect public health or the environment."
In June 2015, the French Ecology Minister asked nurseries and garden centers to halt over-the-counter sales of glyphosate in the form of Monsanto's Roundup. This was a nonbinding request and all sales of glyphosate remain legal in France until 2022, when it was planned to ban the substance for home gardening. However, more recently the French parliament decided to not to impose a definitive date for such a ban. In January 2019, "the sale, distribution, and use of Roundup 360 [wa]s banned" in France. Exemptions for many farmers were later implemented, and a curb of its use by 80% for 2021 is projected.
A vote on the relicensing of glyphosate in the EU stalled in March 2016. Member states France, Sweden, and the Netherlands objected to the renewal. A vote to reauthorize on a temporary basis failed in June 2016 but at the last-minute the license was extended for 18 months until the end of 2017.
On 27 November 2017, a majority of eighteen EU member states voted in favor of permitting the use of herbicide glyphosate for five more years. A qualified majority of sixteen states representing 65% of EU citizens was required. The German Minister of Agriculture, Christian Schmidt, unexpectedly voted in favor while the German coalition government was internally divided on the issue which usually results in Germany abstaining.
In December 2018, attempts were made to reopen the decision to license the weed-killer. These were condemned by Conservative MEPs, who said the proposal was politically motivated and flew in the face of scientific evidence.
In March 2019, the European Court of Justice (ECJ) ordered the European Food Safety Authority (EFSA) to release all carcinogenicity and toxicity pesticide industry studies on glyphosate to the general public.
In March 2019, the Austrian state of Carinthia outlawed the private use of glyphosate in residential areas while the commercial application of the herbicide is still permitted for farmers. The use of glyphosate by public authorities and road maintenance crews was already halted a number of years prior to the current ban by local authorities.
In June 2019, Deutsche Bahn and Swiss Federal Railways announced that glyphosate and other commonly used herbicides for weed eradication along railway tracks will be phased out by 2025, while more environmentally sound methods for vegetation control are implemented.
In September 2019, the German Environment Ministry announced that the use of glyphosate will be banned from the end of 2023. The use of glyphosate-based herbicides will be reduced from 2020.
The assessment process for an approval of glyphosate in the European Union will begin in December 2019. France, Hungary, the Netherlands and Sweden will jointly assess the application dossiers of the producers. The draft report of the assessment group will then be peer-reviewed by the ESFA before the current approval expires in December 2022.
In May 2015, the President of Sri Lanka banned the use and import of glyphosate, effective immediately. However, in May 2018 the Sri Lankan government decided to re-authorize its use in the plantation sector.
In May 2015, Colombia announced that it would stop using glyphosate by October 2015 in the destruction of illegal plantations of coca, the raw ingredient for cocaine. Farmers have complained that the aerial fumigation has destroyed entire fields of coffee and other legal produce.
Lawsuits claiming liability for cancer
In June 2018, Dewayne Johnson, a 46-year-old former California school groundskeeper who is dying of non-Hodgkin lymphoma, took Monsanto (which had been acquired by Bayer earlier that month) to trial in San Francisco County superior court, alleging that it has spent decades hiding the cancer-causing dangers of its Roundup herbicides. The judge ordered that jurors be allowed to consider both scientific evidence related to the cause of Johnson's cancer and allegations that Monsanto suppressed evidence of the risks, with possible punitive damages. In August 2018, the jury awarded Johnson US$289 million in damages. Monsanto said they would appeal, saying they were confident that glyphosate does not cause cancer when used appropriately. In November 2018, the award was reduced to $78 million on appeal.
In August 2018, the potential for additional cases was estimated at up to 4,000. Bayer announced in April 2019 that over 13,000 lawsuits related to Roundup had been launched in the US.
In March 2019, a man was awarded $80 million in a lawsuit claiming Roundup was a substantial factor in his cancer, resulting in Costco stores discontinuing sales. In July 2019, U.S. District Judge Vince Chhabria reduced the settlement to $26 million. Chhabria stated that a punitive award was appropriate because the evidence "easily supported a conclusion that Monsanto was more concerned with tamping down safety inquiries and manipulating public opinion than it was with ensuring its product is safe." Chhabria stated that there is evidence is on both sides concerning whether glyphosate causes cancer and that the behavior of Monsanto showed "a lack of concern about the risk that its product might be carcinogenic."
On 13 May 2019 a jury in California ordered Bayer to pay a couple $2 billion in damages after finding that the company had failed to adequately inform consumers of the possible carcinogenicity of Roundup. On July 26, 2019, an Alameda County judge cut the settlement to $86.7 million, stating that the judgement by the jury exceeded legal precedent.
Using litigation discovery emails it was later revealed that in 2015 when Monsanto was discussing papers they wanted to see published to counter the expected IARC glyphosate results they wrote in an email, "An option would be to add Greim and Kier or Kirkland to have their names on the publication, but we would be keeping the cost down by us doing the writing and they would just edit & sign their names so to speak. Recall that is how we handled Williams Kroes & Munro, 2000."
In June 2020 Bayer, which acquired Monsanto in 2018, agreed to a $10 billion settlement as a result of a number of class-action lawsuits alleging that Roundup had caused cancer.
The New York Times reported that in 1996, "Dennis C. Vacco, the Attorney General of New York, ordered the company Monsanto to pull ads that said Roundup was "safer than table salt" and "practically nontoxic" to mammals, birds and fish. The company withdrew the spots, but also said that the phrase in question was permissible under E.P.A. guidelines."
In 2001, French environmental and consumer rights campaigners brought a case against Monsanto for misleading the public about the environmental impact of its herbicide Roundup, on the basis that glyphosate, Roundup's main component, is classed as "dangerous for the environment" and "toxic for aquatic organisms" by the European Union. Monsanto's advertising for Roundup had presented it as biodegradable and as leaving the soil clean after use. In 2007, Monsanto was convicted of false advertising and was fined 15,000 euros. Monsanto's French distributor Scotts France was also fined 15,000 euros. Both defendants were ordered to pay damages of 5,000 euros to the Brittany Water and Rivers Association and 3,000 euros to the Consommation Logement Cadre de vie, one of the two main general consumer associations in France. Monsanto appealed and the court upheld the verdict; Monsanto appealed again to the French Supreme Court, and in 2009 it also upheld the verdict.
In 2016, a lawsuit was filed against Quaker Oats in the Federal district courts of both New York and California after trace amounts of glyphosate were found in oatmeal. The lawsuit alleged that the claim of "100% natural" was false advertising. That same year General Mills dropped the label "Made with 100% Natural Whole Grain Oats" from their Nature Valley granola bars after a lawsuit was filed that claimed the oats contained trace amounts of glyphosate.
Trade dumping allegations
- "glyphosate". Merriam-Webster Dictionary. Retrieved June 28, 2020.
- "glyphosate". Dictionary.com Unabridged. Random House. Retrieved June 28, 2020.
- "glyphosate". The American Heritage Dictionary of the English Language (5th ed.). Boston: Houghton Mifflin Harcourt. Retrieved June 28, 2020.
- Glyphosate, Environmental Health Criteria monograph No. 159, Geneva: World Health Organization, 1994, ISBN 92-4-157159-4
- Index no. 607-315-00-8 of Annex VI, Part 3, to Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. OJEU L353, 31.12.2008, pp 1–1355 at pp 570, 1100..
- United States EPA 2007 Pesticide Market Estimates Agriculture, Home and Garden
- Myers JP, Antoniou MN, Blumberg B, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R, Vandenberg LN, vom Saal FS, Welshons WV, Benbroo CM (February 17, 2016). "Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement". Environmental Health. 15 (19): 13. doi:10.1186/s12940-016-0117-0. PMC 4756530. PMID 26883814.
- Cressey D (March 25, 2015). "Widely used herbicide linked to cancer". Nature. doi:10.1038/nature.2015.17181. S2CID 131732731.
- Renewal Assessment Report: Glyphosate. Volume 1. Report and Proposed Decision. December 18, 2013. German Institute for Risk Assessment, page 65. Downloaded from http://dar.efsa.europa.eu/dar-web/provision (registration required)
- Schinasi L, Leon ME (April 2014). "Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis". International Journal of Environmental Research and Public Health. 11 (4): 4449–527. doi:10.3390/ijerph110404449. PMC 4025008. PMID 24762670.
- Guyton KZ, Loomis D, Grosse Y, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H, Straif K (May 2015). "Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate". The Lancet. Oncology. 16 (5): 490–91. doi:10.1016/S1470-2045(15)70134-8. PMID 25801782.
- "Press release: IARC Monographs Volume 112: evaluation of five organophosphate insecticides and herbicides" (PDF). International Agency for Research on Cancer, World Health Organization. March 20, 2015.
- "Glyphosate" (PDF). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. International Agency for Research on Cancer. 112. August 11, 2016. Retrieved July 31, 2019.
- "European Food Safety Authority – Glyphosate report" (PDF). EFSA. Retrieved May 23, 2016.
- "Glyphosate: EFSA updates toxicological profile | European Food Safety Authority". Efsa.europa.eu. November 12, 2015. Retrieved May 23, 2016.
- "Report of the Joint Committee on Pesticide Residues, WHO/FAO, Geneva, 16 May, 2016" (PDF).
- "Glyphosate not classified as a carcinogen by ECHA". ECHA. March 15, 2017.
- Dill GM, Sammons RD, Feng PC, Kohn F, Kretzmer K, Mehrsheikh A, Bleeke M, Honegger JL, Farmer D, Wright D, Haupfear EA (2010). "Glyphosate: Discovery, Development, Applications, and Properties" (PDF). In Nandula VK (ed.). Glyphosate Resistance in Crops and Weeds: History, Development, and Management. Hoboken, NJ: Wiley. ISBN 978-0-470-41031-8.
- "Patent Images". 1.usa.gov. Archived from the original on September 12, 2015.
- Alibhai MF, Stallings WC (March 2001). "Closing down on glyphosate inhibition – with a new structure for drug discovery". Proceedings of the National Academy of Sciences of the United States of America. 98 (6): 2944–46. Bibcode:2001PNAS...98.2944A. doi:10.1073/pnas.061025898. JSTOR 3055165. PMC 33334. PMID 11248008.
- "Monsanto's John E. Franz Wins 1990 Perkin Medal". Chemical & Engineering News. 68 (11): 29–30. March 12, 1990. doi:10.1021/cen-v068n011.p029.
- "Glyphosate fact sheet". Pesticides News. Pesticide Action Network UK (33): 28–29. September 1996. Archived from the original on August 23, 2016.
- "The National Medal of Technology and Innovation Recipients – 1987". The United States Patent and Trademark Office. Retrieved November 29, 2012.
- Stong C (May 1990). "People: Monsanto Scientist John E. Franz Wins 1990 Perkin Medal For Applied Chemistry". The Scientist. 4 (10): 28.
- "SCI Perkin Medal". Science History Institute. May 31, 2016. Retrieved March 24, 2018.
- Duke SO, Powles SB (2008), "Glyphosate: a once-in-a-century herbicide: Mini-review" (PDF), Pest Management Science, 64 (4): 319–25, doi:10.1002/ps.1518, PMID 18273882
- "History of Monsanto's Glyphosate Herbicides" (PDF). Monsanto. Retrieved December 20, 2015.
- US application 3799758, John E. Franz, "N-phosphonomethyl-glycine phytotoxicant compositions", published 1974-03-26, assigned to Monsanto Company
- US application 4405531, John E. Franz, "Salts of N-phosphonomethylglycine", published 1983-09-20, assigned to Monsanto Company
- Fernandez, Ivan (May 15, 2002). "The Glyphosate Market: A 'Roundup'". Frost & Sullivan. Archived from the original on March 4, 2016. Retrieved March 10, 2015.
- Powles SB (January 2010). "Gene amplification delivers glyphosate-resistant weed evolution". Proceedings of the National Academy of Sciences of the United States of America. 107 (3): 955–56. Bibcode:2010PNAS..107..955P. doi:10.1073/pnas.0913433107. PMC 2824278. PMID 20080659.
- "Frequently Asked Questions on the Re-evaluation of Glyphosate". Pest Management Regulatory Agency of Canada. April 28, 2017. Retrieved May 10, 2018.
- Chenier, Philip J. (2012). Survey of Industrial Chemistry (3rd ed.). Springer Science+Business Media. p. 384. ISBN 978-1461506034.
- Schuette J. "Environmental Fate of Glyphosate" (PDF). Department of Pesticide Regulation, State of California. Archived from the original (PDF) on April 20, 2012. Retrieved June 4, 2012.
- Zhou J, Li J, An R, Yuan H, Yu F (2012). "Study on a New Synthesis Approach of Glyphosate". J. Agric. Food Chem. 60 (25): 6279–85. doi:10.1021/jf301025p. PMID 22676441.
- International Agency for Research on Cancer (2006). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 88: Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol. Lyon: IARC/WHO. ISBN 978-9283212881.
- National Toxicology Program (June 2011). Report on Carcinogens (12th ed.). Department of Health and Human Services, Public Health Service, National Toxicology Program.
- FAO (2014). FAO specifications and evaluations for agricultural pesticides: glyphosate (PDF). . Food and Agriculture Organization of the United Nations. p. 5.
- European Food Safety Authority (2015). "Conclusion on the peer review of the pesticide risk assessment of the active substance glyphosate". EFSA Journal. 13 (11:4302): 10. doi:10.2903/j.efsa.2015.4302.
- Farm Chemicals International Glyphosate entry in Crop Protection Database
- Alberta Agriculture and Rural Development. April 26, 2006. Quick Guide to Glyphosate Products – Frequently Asked Questions Archived July 26, 2017, at the Wayback Machine
- Hartzler, Bob. "Glyphosate: a Review". ISU Weed Science Online. Iowa State University Extension. Archived from the original on May 18, 2018. Retrieved August 26, 2012.
- Tu M, Hurd C, Robison R, Randall JM (November 1, 2001). "Glyphosate" (PDF). Weed Control Methods Handbook. The Nature Conservancy.
- National Pesticide Information Center. Last updated September 2010 Glyphosate General Fact Sheet
- "Press Release: Research and Markets: Global Glyphosate Market for Genetically Modified and Conventional Crops 2013–2019". Reuters. April 30, 2014. Archived from the original on September 24, 2015.
- monsanto.ca: "Vision Silviculture Herbicide", 03-FEB-2011
- China Research & Intelligence, June 5, 2013. Research Report on Global and China Glyphosate Industry, 2013–2017 Archived March 3, 2016, at the Wayback Machine
- Tu M, Randall JM (June 1, 2003). "Glyphosate" (PDF). Weed Control Methods Handbook. The Nature Conservancy.
- Curran WS, McGlamery MD, Liebl RA, Lingenfelter DD (1999). "Adjuvants for Enhancing Herbicide Performance". Penn State Extension.
- VanGessel M. "Glyphosate Formulations". Control Methods Handbook, Chapter 8, Adjuvants: Weekly Crop Update. University of Delaware Cooperative Extension. Archived from the original on June 13, 2010. Retrieved August 27, 2012.
- "e-phy". e-phy.agriculture.gouv.fr.
- Funke T, Han H, Healy-Fried ML, Fischer M, Schönbrunn E (August 2006). "Molecular basis for the herbicide resistance of Roundup Ready crops". Proceedings of the National Academy of Sciences of the United States of America. 103 (35): 13010–15. Bibcode:2006PNAS..10313010F. doi:10.1073/pnas.0603638103. JSTOR 30050705. PMC 1559744. PMID 16916934.
- Maeda H, Dudareva N (2012). "The shikimate pathway and aromatic amino Acid biosynthesis in plants". Annual Review of Plant Biology. 63: 73–105. doi:10.1146/annurev-arplant-042811-105439. PMID 22554242.
The AAA pathways consist of the shikimate pathway (the prechorismate pathway) and individual postchorismate pathways leading to Trp, Phe, and Tyr.... These pathways are found in bacteria, fungi, plants, and some protists, but are absent in animals. Therefore, AAAs and some of their derivatives (vitamins) are essential nutrients in the human diet, although in animals Tyr can be synthesized from Phe by Phe hydroxylase....The absence of the AAA pathways in animals also makes these pathways attractive targets for antimicrobial agents and herbicides.
- Steinrücken HC, Amrhein N (June 1980). "The herbicide glyphosate is a potent inhibitor of 5-enolpyruvyl-shikimic acid-3-phosphate synthase". Biochemical and Biophysical Research Communications. 94 (4): 1207–12. doi:10.1016/0006-291X(80)90547-1. PMID 7396959.
- "Glyphosate technical fact sheet (revised June 2015)". National Pesticide Information Center. 2010. Archived from the original on 2011. Retrieved September 1, 2015.
- "The agronomic benefits of glyphosate in Europe" (PDF). Monsanto Europe SA. February 2010. Retrieved June 2, 2013.
- Hock B, Elstner EF (2004). Plant Toxicology, Fourth Edition. CRC Press. pp. 292–96. ISBN 978-0-203-02388-4.
- Purdue University, Department of Horticulture and Landscape Architecture, Metabolic Plant Physiology Lecture notes, Aromatic amino acid biosynthesis, The shikimate pathway – synthesis of chorismate.
- Schönbrunn E, Eschenburg S, Shuttleworth WA, Schloss JV, Amrhein N, Evans JN, Kabsch W (February 2001). "Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 1376–80. Bibcode:2001PNAS...98.1376S. doi:10.1073/pnas.98.4.1376. PMC 29264. PMID 11171958.
- Glyphosate bound to proteins in the Protein Data Bank
- Schulz A, Krüper A, Amrhein N (1985). "Differential sensitivity of bacterial 5-enolpyruvylshikimate-3-phosphate synthases to the herbicide glyphosate". FEMS Microbiology Letters. 28 (3): 297–301. doi:10.1111/j.1574-6968.1985.tb00809.x.
- Pollegioni L, Schonbrunn E, Siehl D (August 2011). "Molecular basis of glyphosate resistance-different approaches through protein engineering". The FEBS Journal. 278 (16): 2753–66. doi:10.1111/j.1742-4658.2011.08214.x. PMC 3145815. PMID 21668647.
- Knezevic SZ (February 2010). "Use of Herbicide-Tolerant Crops as Part of an Integrated Weed Management Program". University of Nebraska Extension Integrated Weed Management Specialist. Archived from the original on June 15, 2010.
- Nyamai PA, Prather TS, Wallace JM (2011). "Evaluating Restoration Methods across a Range of Plant Communities Dominated by Invasive Annual Grasses to Native Perennial Grasses". Invasive Plant Science and Management. 4 (3): 306–16. doi:10.1614/IPSM-D-09-00048.1. S2CID 84696972.
- Luijendijk CD, Beltman WH, Smidt RA, van der Pas LJ, Kempenaar C (May 2005). "Measures to reduce glyphosate runoff from hard surfaces" (PDF). Plant Research International B.V. Wageningen.
- Botta F, Lavison G, Couturier G, Alliot F, Moreau-Guigon E, Fauchon N, Guery B, Chevreuil M, Blanchoud H (September 2009). "Transfer of glyphosate and its degradate AMPA to surface waters through urban sewerage systems". Chemosphere. 77 (1): 133–39. Bibcode:2009Chmsp..77..133B. doi:10.1016/j.chemosphere.2009.05.008. PMID 19482331.
- BBC. May 10, 2015. Colombia to ban coca spraying herbicide glyphosate
- MacLean, Amy-Jean. "Desiccant vs. Glyphosate: know your goals". PortageOnline.com. Golden West. Archived from the original on July 31, 2019. Retrieved August 19, 2016.
- "Crop Desiccation". Sustainable Agricultural Innovations & Food. University of Saskatchewan. October 25, 2016. Archived from the original on July 31, 2019. Retrieved July 31, 2019.
- In agriculture, the term desiccant is applied to an agent that promotes dry down. "True desiccants" are not chemical desiccants either, rather the distinction is whether an agent is a contact herbicide such as Diquat and sodium chlorate that rapidly kill the above-ground portion of the plant as it dries out over a few days, or an agent such as glyphosate that is absorbed systemically and translocated to the root, a process that can take days to weeks.
- Sprague, Christy. "Preharvest herbicide applications are an important part of direct-harvest dry bean production". Michigan State University. Michigan State University Extension, Department of Plant, Soil and Microbial Sciences. Retrieved August 20, 2015.
- Gravois, Kenneth (August 14, 2017). "Sugarcane Ripener Recommendations". LSU AgCenter. Louisiana State University, College of Agriculture. Archived from the original on September 20, 2018.
- "Pre-harvest Management of Small Grains". Minnesota Crop News. University of Minnesota Extension. July 18, 2017. Archived from the original on May 27, 2019.
- Fowler, D.B. "Harvesting, Grain Drying and Storage – Chapter 23". Winter Wheat Production Manual. University of Saskatchewan. Archived from the original on December 9, 2018. Retrieved May 3, 2017.
- Green JM, Owen MD (June 2011). "Herbicide-resistant crops: utilities and limitations for herbicide-resistant weed management". Journal of Agricultural and Food Chemistry. 59 (11): 5819–29. doi:10.1021/jf101286h. PMC 3105486. PMID 20586458.
- Rashid A (2009). Introduction to Genetic Engineering of Crop Plants: Aims and Achievements. I K International. p. 259. ISBN 978-93-80026-16-9.
- "Company History". Web Site. Monsanto Company.
- "Adoption of Genetically Engineered Crops in the U.S." Economic Research Service. USDA. Retrieved August 26, 2015.
- Borggaard OK, Gimsing AL (April 2008). "Fate of glyphosate in soil and the possibility of leaching to ground and surface waters: a review". Pest Management Science. 64 (4): 441–56. doi:10.1002/ps.1512. PMID 18161065.
- Botta F, Lavisonb G, Couturier G, Alliot F, Moreau-Guigon E, Fauchon N, Guery B, Chevreuil M, Blanchoud H (2009). "Transfer of glyphosate and its degradate AMPA to surface waters through urban sewerage systems". Chemosphere. 77 (1): 133–139. Bibcode:2009Chmsp..77..133B. doi:10.1016/j.chemosphere.2009.05.008. PMID 19482331.
- Battaglin, W.A.; Meyer, M.T.; Kuivila, K.M.; Dietze, J.E. (April 2014). "Glyphosate and Its Degradation Product AMPA Occur Frequently and Widely in U.S. Soils, Surface Water, Groundwater, and Precipitation". JAWRA Journal of the American Water Resources Association. 50 (2): 275–90. Bibcode:2014JAWRA..50..275B. doi:10.1111/jawr.12159.
- Mahler, Barbara J.; Van Metre, Peter C.; Burley, Thomas E.; Loftin, Keith A.; Meyer, Michael T.; Nowell, Lisa H. (February 2017). "Similarities and differences in occurrence and temporal fluctuations in glyphosate and atrazine in small Midwestern streams (USA) during the 2013 growing season". Science of the Total Environment. 579: 149–58. Bibcode:2017ScTEn.579..149M. doi:10.1016/j.scitotenv.2016.10.236. PMID 27863869.
- Richards, Brian K.; Pacenka, Steven; Meyer, Michael T.; Dietze, Julie E.; Schatz, Anna L.; Teuffer, Karin; Aristilde, Ludmilla; Steenhuis, Tammo S. (April 23, 2018). "Antecedent and Post-Application Rain Events Trigger Glyphosate Transport from Runoff-Prone Soils". Environmental Science & Technology Letters. 5 (5): 249–54. doi:10.1021/acs.estlett.8b00085.
- Muniraa S, Farenhorsta A, Flatena D, Grant C (2016). "Phosphate fertilizer impacts on glyphosate sorption by soil". Chemosphere. 153: 471–77. Bibcode:2016Chmsp.153..471M. doi:10.1016/j.chemosphere.2016.03.028. hdl:1993/31877. PMID 27035384.
- Kanissery RG, Welsh A, Sims GK (2014). "Effect of soil aeration and phosphate addition on the microbial bioavailability of 14C-glyphosate". Journal of Environmental Quality. 44 (1): 137–44. doi:10.2134/jeq2014.08.0331. PMID 25602328. S2CID 31227173.
- "Registration Decision Fact Sheet for Glyphosate (EPA-738-F-93-011)" (PDF). R.E.D. FACTS. United States Environmental Protection Agency. 1993.
- Giesy JP, Dobson S, Solomon KR (2000). "Ecotoxicological risk assessment for Roundup® herbicide". Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology. 167. pp. 35–120. doi:10.1007/978-1-4612-1156-3_2. ISBN 978-0-387-95102-7.
- Torstensson NT, Lundgren LN, Stenström J (October 1989). "Influence of climatic and edaphic factors on persistence of glyphosate and 2,4-D in forest soils". Ecotoxicology and Environmental Safety. 18 (2): 230–39. doi:10.1016/0147-6513(89)90084-5. PMID 2806176.
- Albers CN, Banta GT, Hansen PE, Jacobsen OS (October 2009). "The influence of organic matter on sorption and fate of glyphosate in soil--comparing different soils and humic substances". Environmental Pollution. 157 (10): 2865–70. doi:10.1016/j.envpol.2009.04.004. PMID 19447533.
- Ole K, Borggaard OK (2011). "Does phosphate affect soil sorption and degradation of glyphosate? – A review". Trends in Soil Science and Plant Nutrition. 2 (1): 17–27.[permanent dead link]
- Sparling DW, Matson C, Bickham J, Doelling-Brown P (2006). "Toxicity of glyphosate as Glypro® and LI700 to red-eared slider (Trachemys scripta elegans) embryos and early hatchlings". Environmental Toxicology and Chemistry. 25 (10): 2768–74. doi:10.1897/05-152.1. PMID 17022419.
- European Commission (2017). "EU Pesticides database: Glyphosate". Retrieved August 29, 2018.
- European Food Safety Authority (July 2018). "The 2016 European Union report on pesticide residues in food". EFSA Journal. 16 (7): 67. doi:10.2903/j.efsa.2018.5348. PMID 32625983.
- Van Bruggen AC, He MM, Shin K, Mai V, Jeong KC, Finckh MR, Morris JG (March 2018). "Environmental and health effects of the herbicide glyphosate". Sci. Total Environ. 616–17: 255–68. Bibcode:2018ScTEn.616..255V. doi:10.1016/j.scitotenv.2017.10.309. PMID 29117584.
- Sribanditmongkol P, Jutavijittum P, Pongraveevongsa P, Wunnapuk K, Durongkadech P (September 2012). "Pathological and toxicological findings in glyphosate-surfactant herbicide fatality: a case report". The American Journal of Forensic Medicine and Pathology. 33 (3): 234–37. doi:10.1097/PAF.0b013e31824b936c. PMID 22835958. S2CID 3457850.
- Bradberry SM, Proudfoot AT, Vale JA (2004). "Glyphosate poisoning". Toxicological Reviews. 23 (3): 159–67. doi:10.2165/00139709-200423030-00003. PMID 15862083. S2CID 5636017.
- Glyphosate: Human Health and Ecological Risk Assessment (PDF), Syracuse Environmental Research Associates, Inc.(SERA), retrieved August 20, 2018
- "Committee of Risk Assessment Opinion proposing harmonised classification and labelling at EU level of glyphosate (ISO); N-(phosphonomethyl)glycine".
- Tarazona, Jose V.; Court-Marques, Daniele; Tiramani, Manuela; Reich, Hermine; Pfeil, Rudolf; Istace, Frederique; Crivellente, Federica (April 3, 2017). "Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC". Archives of Toxicology. 91 (8): 2723–43. doi:10.1007/s00204-017-1962-5. PMC 5515989. PMID 28374158.
- Boobis, Alan R. (2016). Pesticide residues in food 2016, Joint FAO/WHO Meeting on Pesticide Residues, 9–13 May 2016 (PDF). Rome: WHO/FAO. pp. 19–28. ISBN 978-92-5-109246-0.
- Guston, David; Ludlow, Karinne (2010). "Australian Pesticides and Veterinary Medicines Authority". Encyclopedia of Nanoscience and Society. Thousand Oaks, CA: SAGE Publications, Inc. ISBN 978-1-4129-6987-1.
- "The BfR has finalised its draft report for the re-evaluation of glyphosate – BfR". Retrieved August 18, 2018.
- US EPA, OCSPP (December 18, 2017). "EPA Releases Draft Risk Assessments for Glyphosate" (Announcements and Schedules). US EPA. Retrieved August 18, 2018.
- Cancer Assessment Review Committee, HED, Office of Pesticides Program, US EPA (October 1, 2015). Evaluation of the Carcinogenic potential of Glyphosate, Final Report. Washington: US EPA. pp. 77–78.CS1 maint: multiple names: authors list (link)
- "Food Controversies – Pesticides and organic foods". Cancer Research UK. 2016. Retrieved November 28, 2017.
- Chang ET, Delzell E (2016). "Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers". Journal of Environmental Science and Health, Part B. 51 (6): 402–34. doi:10.1080/03601234.2016.1142748. PMC 4866614. PMID 27015139.
- Sass, Jennifer (February 20, 2018). "Monsanto Mouthpieces: House Science Committee, EPA, EU-EFSA". Natural Resources Defense Council. Retrieved May 6, 2019.
- Zhang, L.; Rana, I.; Shaffer, R. M.; Taioli, E.; Sheppard, L. (2019). "Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence". Mutation Research. 781: 186–206. doi:10.1016/j.mrrev.2019.02.001. PMC 6706269. PMID 31342895.
- Kimmel GL, Kimmel CA, Williams AL, DeSesso JM (2013). "Evaluation of developmental toxicity studies of glyphosate with attention to cardiovascular development". Critical Reviews in Toxicology. 43 (2): 79–95. doi:10.3109/10408444.2012.749834. PMC 3581053. PMID 23286529.
- Gress S, Lemoine S, Séralini GE, Puddu PE (April 2015). "Glyphosate-based herbicides potently affect cardiovascular system in mammals: review of the literature". Cardiovascular Toxicology. 15 (2): 117–26. doi:10.1007/s12012-014-9282-y. PMID 25245870. S2CID 17936407.
- Abraham William Wildwood. Glyphosate formulations and their use for inhibition of 5-enolpyrovylshikimate-3-phosphate synthase, US Patent 7, 771, 736 B2; 2010
- Roberts CW, Roberts F, Lyons RE, Kirisits MJ, Mui EJ, Finnerty J, Johnson JJ, Ferguson DJ, Coggins JR, Krell T, Coombs GH, Milhous WK, Kyle DE, Tzipori S, Barnwell J, Dame JB, Carlton J, McLeod R (February 2002). "The shikimate pathway and its branches in apicomplexan parasites". The Journal of Infectious Diseases. 185 (Suppl 1): S25–36. doi:10.1086/338004. PMID 11865437.
- Zablotowicz RM, Reddy KN (2004). "Impact of glyphosate on the Bradyrhizobium japonicum symbiosis with glyphosate-resistant transgenic soybean: a minireview". Journal of Environmental Quality. 33 (3): 825–31. doi:10.2134/jeq2004.0825. PMID 15224916.
- Andréa MM, Peres TB, Luchini LC, Bazarin S, Papini S, Matallo MB, Savoy VL (2003). "Influence of repeated applications of glyphosate on its persistence and soil bioactivity". Pesquisa Agropecuária Brasileira. 38 (11): 1329–35. doi:10.1590/S0100-204X2003001100012.
- Cerdeira AL, Duke SO (January 2010). "Effects of glyphosate-resistant crop cultivation on soil and water quality" (PDF). GM Crops. 1 (1): 16–24. doi:10.4161/gmcr.1.1.9404. PMID 21912208. S2CID 38119904.
- Nguyen DB, Rose MT, Rose TJ, Morris SG, van Zwieten L (2016). "Impact of glyphosate on soil microbial biomass and respiration: A meta-analysis". Soil Biology and Biochemistry. 92: 50–57. doi:10.1016/j.soilbio.2015.09.014. ISSN 0038-0717.
- Rose MT, Cavagnaro TR, Scanlan CA, Rose TJ, Vancov T, Kimber S, Kennedy IR, Kookana RS, Van Zwieten L (2016). Impact of Herbicides on Soil Biology and Function. Advances in Agronomy. 136. p. 168. doi:10.1016/bs.agron.2015.11.005. ISBN 978-0128046814.
- United States Environmental Protection Agency (June 18, 2007). "Draft List of Initial Pesticide Active Ingredients and Pesticide Inerts to be Considered for Screening under the Federal Food, Drug, and Cosmetic Act" (PDF). Federal Register. 72 (116): 33486–503.
- United States Environmental Protection Agency (June 29, 2015). "Memorandum: EDSP Weight of Evidence Conclusions on the Tier 1 Screening Assays for the List 1 Chemicals" (PDF). Archived from the original (PDF) on January 16, 2016.
- European Food Safety Authority (EFSA) (September 2017). "Peer review of the pesticide risk assessment of the potential endocrine disrupting properties of glyphosate". EFSA Journal. 15 (9): e04979. doi:10.2903/j.efsa.2017.4979. PMC 7010201. PMID 32625644.
- Duke SO, Wedge DE, Cerdeira AL, Matallo MB (2007). "Interactions of Synthetic Herbicides with Plant Disease and Microbial Herbicides". In Vurro M, Gressel J (eds.). Novel Biotechnologies for Biocontrol Agent Enhancement and Management. NATO Security through Science Series. pp. 277–96. doi:10.1007/978-1-4020-5799-1_15. ISBN 978-1-4020-5797-7.
- Rosenblueth M, Martínez-Romero E (August 2006). "Bacterial endophytes and their interactions with hosts". Molecular Plant-Microbe Interactions. 19 (8): 827–37. doi:10.1094/MPMI-19-0827. PMID 16903349.
- "Pesticide Registration Manual | Pesticide Registration | US EPA". March 4, 2013.
- "Adjuvants for Enhancing Herbicide Performance". extension.psu.edu. Penn State Extension. Retrieved August 15, 2018.
- "Measuring POEA, a Surfactant Mixture in Herbicide Formulations". U.S. Geological Survey.
- Gary L. Diamond and Patrick R. Durkin February 6, 1997, under contract from the United States Department of Agriculture. Effects of Surfactants on the Toxicity of Glyphosate, with Specific Reference to RODEO
- "SS-AGR-104 Safe Use of Glyphosate-Containing Products in Aquatic and Upland Natural Areas" (PDF). University of Florida. Retrieved August 13, 2018.
- Mann RM, Hyne RV, Choung CB, Wilson SP (2009). "Amphibians and agricultural chemicals: Review of the risks in a complex environment". Environmental Pollution. 157 (11): 2903–27. doi:10.1016/j.envpol.2009.05.015. PMID 19500891.
- "Ecotoxicological Risk Assessment for Roundup Herbicide" (PDF). Retrieved May 9, 2019.
- Talbot AR, Shiaw MH, Huang JS, Yang SF, Goo TS, Wang SH, Chen CL, Sanford TR (January 1991). "Acute poisoning with a glyphosate-surfactant herbicide ('Roundup'): a review of 93 cases". Human & Experimental Toxicology. 10 (1): 1–8. doi:10.1177/096032719101000101. PMID 1673618. S2CID 8028945.
- Williams GM, Kroes R, Munro IC (April 2000). "Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans". Regulatory Toxicology and Pharmacology. 31 (2 Pt 1): 117–65. doi:10.1006/rtph.1999.1371. PMID 10854122. S2CID 19831028.
- Mink PJ, Mandel JS, Sceurman BK, Lundin JI (August 2012). "Epidemiologic studies of glyphosate and cancer: a review". Regulatory Toxicology and Pharmacology. 63 (3): 440–52. doi:10.1016/j.yrtph.2012.05.012. PMID 22683395.
- de Araujo JS, Delgado IF, Paumgartten FJ (June 2016). "Glyphosate and adverse pregnancy outcomes, a systematic review of observational studies". BMC Public Health. 16: 472. doi:10.1186/s12889-016-3153-3. PMC 4895883. PMID 27267204.
- Mesnage R, Defarge N, Spiroux de Vendômois J, Séralini GE (2015). "Potential toxic effects of glyphosate and its commercial formulations below regulatory limits". Food Chem. Toxicol. 84: 133–53. doi:10.1016/j.fct.2015.08.012. PMID 26282372.
- Govindarajulu PP (2008). "Literature Review of Impacts of Glyphosate Herbicide on Amphibians: What Risks can the Silvicultural Use of this Herbicide Pose for Amphibians in BC?". British Columbia, Ecosystems Branch, Ministry of Environment. CiteSeerX 10.1.1.314.3577. Cite journal requires
- Solomon KR, Thompson DG (2003). "Ecological risk assessment for aquatic organisms from over-water uses of glyphosate". Journal of Toxicology and Environmental Health, Part B. 6 (3): 289–324. doi:10.1080/10937400306468. PMID 12746143. S2CID 42770586.
- Wagner N, Reichenbecher W, Teichmann H, Tappeser B, Lötters S (August 2013). "Questions concerning the potential impact of glyphosate-based herbicides on amphibians". Environmental Toxicology and Chemistry / SETAC. 32 (8): 1688–700. doi:10.1002/etc.2268. PMID 23637092.
- ToxNet. Glyposate. National Library of Medicine.
- "Glyphosate: no more poisonous than previously assumed, although a critical view should be taken of certain co-formulants – BfR". Bfr.bund.de.
- "Glyphosate RAR 01 Volume 1 2013-12-18 San". Renewal Assessment Report. Hungry4Pesticides. December 18, 2013. Retrieved March 27, 2015.
- "Frequently asked questions on the health assessment of glyphosate" (PDF). Bundesinstitut für Risikobewertung. January 15, 2014. Archived from the original (PDF) on October 14, 2015.
- "Conclusion on the peer review of the pesticide risk assessment of the active substance glyphosate". EFSA Journal. 13 (11): 4302. 2015. doi:10.2903/j.efsa.2015.4302.
- Nelson, Arthur (September 14, 2017). "EU report on weedkiller safety copied text from Monsanto study". The Guardian. Retrieved September 30, 2017.
- "Independent scientists warn over Monsanto herbicide". DW. December 1, 2015. Retrieved December 9, 2015.
- Portier, Christopher J.; et al. (November 27, 2015). "Open letter: Review of the Carcinogenicity of Glyphosate by EFSA and BfR" (PDF). Letter to Vytenis Andriukaitis. Retrieved December 9, 2015.
- "Open letter. Subject: Plant protection products – transparency in the context of the decision-making process on glyphosate" (PDF). European Commission. April 4, 2016. Retrieved May 16, 2016.
- Charles D (September 17, 2016). "EPA Weighs In On Glyphosate, Says It Doesn't Cause Cancer". NPR. Retrieved September 19, 2016.
- Charles, Dan. "Emails Reveal Monsanto's Tactics To Defend Glyphosate Against Cancer Fears". NPR. Retrieved May 14, 2019.
- CNN, Holly Yan (May 3, 2019). "The EPA says glyphosate, the main ingredient in Roundup, doesn't cause cancer. Others aren't so sure". CNN. Retrieved May 13, 2019.
- Specter M (April 10, 2015). "Roundup and Risk Assessment". New Yorker.
'Probable' means that there was enough evidence to say it is more than possible, but not enough evidence to say it is a carcinogen," Aaron Blair, a lead researcher on the IARC's study, said. Blair, a scientist emeritus at the National Cancer Institute, has studied the effects of pesticides for years. "It means you ought to be a little concerned about" glyphosate, he said.
- Pollack A (March 27, 2015). "Weed Killer, Long Cleared, Is Doubted". New York Times.
- "Löst Glyphosat Krebs aus? (announcement 007/2015)" (PDF) (in German). German Institute for Risk Assessment. March 23, 2015.
- Butler K (June 15, 2017). "A scientist didn't disclose important data – and let everyone believe a popular weedkiller causes cancer". Mother Jones. Retrieved June 19, 2017.
- "Preamble to the IARC Monographs". International Agency for Research on Cancer. 2006.
- Lerner S (November 3, 2015). "EPA used Monsanto's Research to Give Roundup A Pass". The Intercept.
- Gillam C (March 24, 2015). "Monsanto seeks retraction for report linking herbicide to cancer". Reuters.
- "Glyphosate: IARC (Monsanto shared document)" (PDF). Baum Hedlund Law. February 23, 2015. Retrieved June 3, 2018.
- "Monsanto Papers: Secret Documents". Baum, Hedlund, Aristei & Goldman, PC. Retrieved October 31, 2019.
- McHenry, Leemon B. (2018). "The Monsanto Papers: Poisoning the scientific well". International Journal of Risk & Safety in Medicine. 29 (3–4): 193–205. doi:10.3233/JRS-180028. ISSN 1878-6847. PMID 29843257.
- "Chemical Industry Documents Library". Retrieved November 2, 2019.
- Hakim, Danny (August 1, 2017). "Monsanto Emails Raise Issue of Influencing Research on Roundup Weed Killer". The New York Times. ISSN 0362-4331. Retrieved October 26, 2019.
- Stéphane Foucart; Stéphane Horel. "The Investigative Reporting Award 2018 Winner: Monsanto Papers". European Press Prize. Retrieved March 31, 2019.
[T]he non-American scientists who had been members of the IARC panel on glyphosate all received the same letter. Sent by Monsanto’s law firm, Hollingsworth, the letter told them to hand over all the files related to their work on Monograph 112.
- Tarazona JV, Court-Marques D, Tiramani M, Reich H, Pfeil R, Istace F, Crivellente F (August 2017). "Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC". Archives of Toxicology. 91 (8): 2723–43. doi:10.1007/s00204-017-1962-5. PMC 5515989. PMID 28374158.
- Portier CJ, et al. (August 2016). "Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)". Journal of Epidemiology and Community Health. 70 (8): 741–45. doi:10.1136/jech-2015-207005. PMC 4975799. PMID 26941213.
- Grossarth, Jan. "Herbizid: Der dramatische Kampf um die Deutungshoheit von Glyphosat". FAZ.NET (in German). ISSN 0174-4909. Retrieved January 6, 2019.
- Editor, Ben Webster, Environment (October 18, 2017). "Weedkiller scientist was paid £120,000 by cancer lawyers". The Times. ISSN 0140-0460. Retrieved January 6, 2019.CS1 maint: extra text: authors list (link)
- Kelland, Kate. "Glyphosate: WHO cancer agency edited out". Reuters. Retrieved January 6, 2019.
- Reuters (January 21, 2016). "Monsanto Sues California Over Herbicide Classification". The New York Times. ISSN 0362-4331. Retrieved January 25, 2016.
- "Monsanto loses cancer label lawsuit, accused of ghostwriting study". St. Louis Business Journal. March 14, 2017. Retrieved June 28, 2017.
- "Glyphosate Listed Effective July 7, 2017, as Known to the State of California to Cause Cancer". oehha.ca.gov. Retrieved July 7, 2017.
- "Federal judge rules against California's attorney general over..." LA Times. Retrieved August 14, 2018.
- "EPA Takes Action to Provide Accurate Risk Information to Consumers, Stop False Labeling on Products". US EPA. August 8, 2019. Retrieved October 28, 2019.
- "Glyphosate not classified as a carcinogen by ECHA". echa.europa.eu.
- "Resisting Roundup". The New York Times. May 16, 2010. Retrieved March 24, 2016.
- Heap, Ian (2014). "Herbicide Resistant Weeds". Integrated Pest Management. pp. 281–301. doi:10.1007/978-94-007-7796-5_12. ISBN 978-94-007-7795-8.
- Lori (May 7, 2009). "U of G Researchers Find Suspected Glyphosate-Resistant Weed". Uoguelph.ca. Retrieved August 22, 2010.
- Heap, Ian Michael (1988). Resistance to herbicides in annual ryegrass (Lolium Rigidum). Adelaide: Department of Agronomy, University of Adelaide.
- King, Carolyn (June 2015). "History of herbicide resistance Herbicide resistance: Then, now, and the years to come". Retrieved March 24, 2016.
- Hartzler B (January 29, 2003), "Are Roundup Ready Weeds in Your Future II", Iowa State University (ISU), Weed Science Online, retrieved March 24, 2016
- Powles SB, Lorraine-Colwill DF, Dellow JJ, Preston C (1998). "Evolved Resistance to Glyphosate in Rigid Ryegrass (Lolium rigidum) in Australia". Weed Science. 46 (5): 604–07. doi:10.1017/S0043174500091165. JSTOR 4045968.
- Glyphosate Resistance in Crops and Weeds: History, Development, and Management. Editor, Vijay K. Nandula. John Wiley & Sons, 2010 ISBN 978-1118043547
- "Glyphosate resistance is a reality that should scare some cotton growers into changing the way they do business". Southeastfarmpress.com. February 10, 2006. Retrieved August 22, 2010.
- "Weeds Resistant to EPSP synthase inhibitors (G/9) – by species and country". The International Survey of Herbicide Resistant Weeds. 2017. Retrieved June 27, 2017. from link, select Glyphosate from dropdown
- Neuman W, Pollack A (May 4, 2010). "U.S. Farmers Cope With Roundup-Resistant Weeds". New York Times. New York. pp. B1. Retrieved May 4, 2010.
- Benbrook, Charles M (2012). "Impacts of genetically engineered crops on pesticide use in the U.S. – the first sixteen years". Environmental Sciences Europe. 24: 24. doi:10.1186/2190-4715-24-24.
- Heap I. "Resistance by Active Ingredient (select "glyphosate" from the pulldown menu)". The International Survey of Herbicide Resistant Weeds. Retrieved April 13, 2014.
- "With BioDirect, Monsanto Hopes RNA Sprays Can Someday Deliver Drought Tolerance and Other Traits to Plants on Demand". MIT Technology Review. Retrieved August 31, 2015.
- Culpepper AS, Grey TL, Vencill WK, Kichler JM, Webster TM, Brown SM, York AC, Davis JW, Hanna WW (2006). "Glyphosate-resistant Palmer amaranth (Amaranthus palmeri) confirmed in Georgia". Weed Science. 54 (4): 620–26. doi:10.1614/WS-06-001R.1. JSTOR 4539441. S2CID 56236569.
- Hampton, Natalie (Winter 2009). "Cotton versus the monster weed". College of Agriculture and Life Science. North Carolina State University.
- Ward, Sarah M.; Webster, Theodore M.; Steckel, Larry E. (January 20, 2017). "Palmer Amaranth (Amaranthus palmeri): A Review". Weed Technology. 27 (1): 12–27. doi:10.1614/WT-D-12-00113.1. S2CID 84142912.
- Smith JT (March 2009). "Resistance a growing problem" (PDF). The Farmer Stockman. Retrieved July 19, 2009.
- Taylor O (July 16, 2009). "Peanuts: variable insects, variable weather, Roundup resistant Palmer in new state". PeanutFax. AgFax Media. Retrieved July 19, 2009.
- Vargas L, Bianchi MA, Rizzardi MA, Agostinetto D, Dal Magro T (2007). "Buva (Conyza bonariensis) resistente ao glyphosate na região sul do Brasil" [Conyza bonariensis biotypes resistant to the glyphosate in southern Brazil]. Planta Daninha (in Portuguese). 25 (3): 573–78. doi:10.1590/S0100-83582007000300017.
- Koger CH, Shaner DL, Henry WB, Nadler-Hassar T, Thomas WE, Wilcut JW (2005). "Assessment of two nondestructive assays for detecting glyphosate resistance in horseweed (Conyza canadensis)". Weed Science. 53 (4): 438–45. doi:10.1614/WS-05-010R. JSTOR 4047050. S2CID 198128423.
- Ge X, d'Avignon DA, Ackerman JJ, Sammons RD (April 2010). "Rapid vacuolar sequestration: the horseweed glyphosate resistance mechanism". Pest Management Science. 66 (4): 345–48. doi:10.1002/ps.1911. PMC 3080097. PMID 20063320.
- Vila-Aiub MM, Vidal RA, Balbi MC, Gundel PE, Trucco F, Ghersa CM (April 2008). "Glyphosate-resistant weeds of South American cropping systems: an overview". Pest Management Science. 64 (4): 366–71. doi:10.1002/ps.1488. PMID 18161884.
- Jhala A (June 4, 2015). "Post-Emergence Herbicide Options for Glyphosate-Resistant Marestail in Corn and Soybean". CropWatch. Nebraska Extension. Retrieved August 17, 2015.
- Preston C, Wakelin AM, Dolman FC, Bostamam Y, Boutsalis P (2009). "A Decade of Glyphosate-Resistant Lolium around the World: Mechanisms, Genes, Fitness, and Agronomic Management". Weed Science. 57 (4): 435–41. doi:10.1614/WS-08-181.1. S2CID 85725624.
- Peerzada, Arslan Masood; et al. (March 16, 2017). "Eco-biology, impact, and management of Sorghum halepense (L.) Pers" (PDF). Biological Invasions. doi:10.1007/s10530-017-1410-8. S2CID 17096998.
- Kniss A (February 10, 2014). "Are herbicides responsible for the decline in Monarch butterflies?". Control Freaks. Retrieved June 16, 2016.
The evidence seems clear that the number of milkweed plants through this region has indeed declined. The cause for the milkweed decline, though, is a little less certain.
- Plumer B (January 29, 2014). "Monarch butterflies keep disappearing. Here's why". The Washington Post. Retrieved June 16, 2016.
- Pleasants JM, Oberhauser KS (2013). "Milkweed loss in agricultural fields because of herbicide use: Effect on the monarch butterfly population". Insect Conservation and Diversity. 6 (2): 135–44. doi:10.1111/j.1752-4598.2012.00196.x. S2CID 14595378.
- Hartzler RG, Buhler DD (2000). "Occurrence of common milkweed (Asclepias syriaca) in cropland and adjacent areas". Crop Protection. 19 (5): 363–66. doi:10.1016/s0261-2194(00)00024-7.
- "NRDC Sues EPA Over Demise of Monarch Butterfly Population". NBC. 2015.
- Vandenberg LN, Blumberg B, Antoniou MN, Benbrook CM, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R, vom Saal FS, Welshons WV, Myers JP (June 2017). "Is it time to reassess current safety standards for glyphosate-based herbicides?" (PDF). J Epidemiol Community Health. 71 (6): 613–18. doi:10.1136/jech-2016-208463. PMC 5484035. PMID 28320775.
- Staff, Sustainable Pulse. Apr 4 2014 Dutch Parliament Bans Glyphosate Herbicides for Non-Commercial Use
- "French minister asks shops to stop selling Monsanto Roundup weedkiller". Reuters. June 14, 2015.
- French parliament does not vote for a date to terminate glyphosate: Rejet à l’Assemblée de l’inscription dans la loi de la date de sortie du glyphosate
- "Weedkiller Roundup banned in France after court ruling". France 24. January 16, 2019. Retrieved January 16, 2019.
- "French court cancels Monsanto weedkiller permit on safety grounds". Reuters. January 15, 2019. Retrieved January 16, 2019.
- Arthur Nelson (March 8, 2016). "Vote on controversial weedkiller's European licence postponed". The Guardian.
- "Recall of Monsanto's Roundup likely as EU refuses limited use of glyphosate". Reuters. June 6, 2016.
- Arthur Nelson (June 29, 2016). "Controversial chemical in Roundup weedkiller escapes immediate ban". The Guardian.
- 'EU votes for five more years usage of herbicide glyphosate'. NRC Handelsblad (in Dutch), 28 November 2017.
- 'Talks CDU-SPD under pressure because of herbicide' (in Dutch). NRC Handelsblad, 28 November 2017.
- "Move to re-open Glyphosate case attacked by Conservative MEPs". Conservative Europe. December 6, 2018.
- ‘European Court of Justice orders public release of industry glyphosate studies’, 7 March 2019.
- "Kärnten verbietet ab 28. März Glyphosat für Private" (in German). Die Presse. Retrieved 29 April 2019.
- Briner M (July 2018). Schluss mit Glyphosat: SBB wollen Unkraut anders vernichten Aargauer Zeitung (in German). Retrieved 26 June 2019.
- Schlesiger Ch (June 2019). Deutsche Bahn will künftig auf Glyphosat verzichten Wirtschaftswoche (in German). Retrieved 26 June 2019.
- Nationalrat stimmt für Glyphosatverbot, Austrian parliament votes to forbid Glyphosphat & water is a public good necessary for the existence of a human, orf.at, 2019-07-02
- Rinke, Andreas (September 4, 2019). "Germany to ban use of glyphosate from end of 2023". Reuters.
- European Commission (July 12, 2017). "Glyphosate Current status of glyphosate in the EU". Retrieved October 29, 2019.
- Staff, Centralamericadata.com. September 6, 2013 El Salvador: Use of 53 Chemicals Banned
- Staff, Centralamericadata.com. November 27, 2013 El Salvador: Confirmation to Be Given on Ban of Agrochemicals
- Legislative Assembly of El Salvador. November 26, 2013 Analizan observaciones del Ejecutivo al decreto que contiene la prohibición de 53 agroquímicos que dañan la salud Archived May 31, 2015, at the Wayback Machine English translation by Google
- Staff, Colombo Page. May 22, 2015 Sri Lankan President orders to ban import of glyphosate with immediate effect
- Sarina Locke for the Australian Broadcasting Corporation. Updated May 27, 2015 Toxicologist critical of 'dodgy science' in glyphosate bans
- "Glyphosate ban lifted for tea, rubber industries: Navin". Daily Mirror. May 2, 2018.
- "Health Minister: importation of roundup weed spray suspended". Bermuda Today. May 11, 2015. Archived from the original on June 2, 2015.
- "Việt Nam bans weed killer ingredient glyphosate". Viet Nam News. April 11, 2019.
- Reuters (October 25, 2019). U.S. protests Thailand's chemical ban would hurt crop exports
- "Thailand reverses ban of chemicals use in pesticides". Reuters. November 27, 2019. Retrieved December 12, 2019.
- Sam Levin (July 24, 2018). "Monsanto's 'cancer-causing' weedkiller destroyed my life, dying man tells court". The Guardian.
- Tessa Stuart (August 14, 2018). "Monsanto's EPA-Manipulating Tactics Revealed in $289 Million Case". Rolling Stone. Retrieved August 15, 2018.
- Carey Gillam (August 11, 2018). "One man's suffering has exposed Monsanto's secrets to the world". The Guardian. Retrieved August 11, 2018.
- "Weedkiller glyphosate 'doesn't cause cancer' – Bayer". BBC News. August 11, 2018. Retrieved August 11, 2018.
- Sullivan, Emily. "Groundskeeper Accepts Reduced $78 Million Award In Monsanto Cancer Suit". NPR. Retrieved July 29, 2019.
- Levin, Sam (August 11, 2018). "Monsanto ordered to pay $289m as jury rules weedkiller caused man's cancer". The Guardian. Retrieved August 13, 2018.
- Gonzales, Richard (March 29, 2019). "Jury Awards $80 Million In Damages In Roundup Weed Killer Cancer Trial". NPR. Retrieved July 29, 2019.
- Wolfson, Andrew (March 28, 2019). "Louisville lawyer wins $80M verdict against Monsanto over weedkiller Roundup". The Courier-Journal. Louisville, KY. Retrieved July 29, 2019.
- Johnson, Stephen (March 29, 2019). "Costco stops selling controversial Roundup weedkiller". Big Think.
- "Judge Reduces $80M Award In Roundup Case; Cancer Patient, Monsanto Both Consider Appeal". KPIX-TV. San Francisco. Associated Press. July 15, 2019. Retrieved July 27, 2019.
- "Bayer's $2 Billion Roundup Damages Boost Pressure to Settle". bloomberg.com. Retrieved May 14, 2019.
- Telford, Taylor (July 26, 2019). "Judge cuts $2 billion award for couple with cancer to $86.7 million in Roundup lawsuit". Washington Post. Retrieved July 27, 2019.
- Rosenblatt, Joel. "Roundup Judge Loosens His Grip on Monsanto Ghosts Haunting Bayer". Bloomberg. Retrieved May 19, 2019.
- Cohen, Patricia (June 24, 2020). "Roundup Maker to Pay $10 Billion to Settle Cancer Suits". The New York Times. ISSN 0362-4331. Retrieved June 25, 2020.
- Charry T (May 29, 1997). "Monsanto recruits the horticulturist of the San Diego Zoo to pitch its popular herbicide". Business Day. New York Times.
- "Monsanto fined in France for 'false' herbicide ads". Terradaily.com (January 26, 2007).
- Europe | Monsanto guilty in 'false ad' row. BBC News (October 15, 2009).
- Strom, Stephanie (December 21, 2017). "Quaker Oats' 100% Natural Claim Questioned in Lawsuit". The New York Times. ISSN 0362-4331. Retrieved August 13, 2018.
- "General Mills drops '100% Natural' on Nature Valley granola bars after lawsuit". USA Today. Retrieved August 25, 2018.
- Hoskins T (April 15, 2010). "Glyphosate maker complains of Chinese dumping". Missouri Farmer Today.
- "In the Matter of: Glyphosate From China" (PDF). United States International Trade Commission. April 22, 2010.
|Wikimedia Commons has media related to Glyphosate.|