Glypican 3

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Aliases GPC3, DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1, Glypican 3
External IDs MGI: 104903 HomoloGene: 20944 GeneCards: GPC3
RNA expression pattern
PBB GE GPC3 209220 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr X: 133.54 – 133.99 Mb Chr X: 52.27 – 52.61 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Glypican-3 is a protein that in humans is encoded by the GPC3 gene.[3][4][5][6] The protein encoded by this gene is a member of the glypican family.

Structure and function[edit]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.[5]

Disease linkage[edit]

Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome.[7]

Diagnostic utility[edit]

Glypican 3 immunostaining has utility for differentiating hepatocellular carcinoma (HCC) and dysplastic changes in cirrhotic livers; HCC stains with glypican 3, while liver with dysplastic changes and/or cirrhotic changes does not.[8]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pilia G, Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, Huber R, Neri G, Cao A, Forabosco A, Schlessinger D (Mar 1996). "Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome". Nat Genet. 12 (3): 241–7. doi:10.1038/ng0396-241. PMID 8589713. 
  4. ^ Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G (Dec 1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics. 53 (1): 1–11. doi:10.1006/geno.1998.5465. PMID 9787072. 
  5. ^ a b "Entrez Gene: GPC3 glypican 3". 
  6. ^ Jakubovic BD, Jothy S (April 2007). "Glypican-3: from the mutations of Simpson-Golabi-Behmel genetic syndrome to a tumor marker for hepatocellular carcinoma". Exp. Mol. Pathol. 82 (2): 184–9. doi:10.1016/j.yexmp.2006.10.010. PMID 17258707. 
  7. ^ Davoodi J, Kelly J, Gendron NH, MacKenzie AE (June 2007). "The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26". Proteomics. 7 (13): 2300–10. doi:10.1002/pmic.200600654. PMID 17549790. 
  8. ^ Anatelli F, Chuang ST, Yang XJ, Wang HL (2008). "Value of glypican 3 immunostaining in the diagnosis of hepatocellular carcinoma on needle biopsy". Am J Clin Pathol. 130 (2): 219–23–8. doi:10.1309/WMB5PX57Y4P8QCTY. PMID 18628090. 

External links[edit]

Further reading[edit]