Go 6976

From Wikipedia, the free encyclopedia
Go 6976
Go 6976.svg
Names
Preferred IUPAC name
3-(13-Methyl-5-oxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)propanenitrile
Other names
PD 406976
Identifiers
3D model (JSmol)
8588138
ChEBI
ChEMBL
ChemSpider
UNII
  • InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
    Key: VWVYILCFSYNJHF-UHFFFAOYSA-N
  • O=C1NCC2=C3C(N(CCC#N)C4=CC=CC=C43)=C5C(C6=CC=CC=C6N5C)=C21
Properties
C24H18N4O
Molar mass 378.435 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Go 6976 (also known as Go-6976 and Goe 6976) is a protein kinase inhibitor.[1][2][3] It has some specificity for protein kinase C alpha and beta, and through their inhibition it is thought to induce the formation of cell junctions, and hence inhibit the invasion of urinary bladder carcinoma cells".[4]

References[edit]

  1. ^ "Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information". druginfo.nlm.nih.gov. United States National Library of Medicine, National Institutes of Health. Retrieved 2019-08-26.
  2. ^ "NCATS Inxight: Drugs — GO-6976". drugs.ncats.io. U.S.: NCATS, United States Department of Health and Human Services. Retrieved 2019-09-29.
  3. ^ Qatsha, KA; Rudolph, C; Marmé, D; Schaechtele, C.; May, MD,PhD, W. (1993-06-01). "Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro". Proceedings of the National Academy of Sciences. 90 (10): 4674–8. Bibcode:1993PNAS...90.4674Q. doi:10.1073/pnas.90.10.4674. PMC 46575. PMID 7685108.
  4. ^ Koivunen, Jussi; Aaltonen, Vesa; Koskela, Sanna; Lehenkari, Petri; Laato, Matti; Peltonen, Juha (2004-08-15). "Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells". Cancer Research. 64 (16): 5693–5701. doi:10.1158/0008-5472.CAN-03-3511. ISSN 0008-5472. PMID 15313909.