Goblet cell carcinoid

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Goblet cell carcinoid
Goblet cell carcinoid -2- high mag.jpg
Micrograph showing a goblet cell carcinoid. H&E stain.
Classification and external resources

The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine tumour with goblet cell differentiation, is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.[1]

Sign and symptoms[edit]

GCCs may present as appendicitis.


Micrograph of a goblet cell carcinoid. H&E stain.

GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).


GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.[1]


GCCs are treated with surgery.

See also[edit]


  1. ^ a b van Eeden S, Offerhaus GJ, Hart AA, et al. (December 2007). "Goblet cell carcinoid of the appendix: a specific type of carcinoma". Histopathology. 51 (6): 763–73. doi:10.1111/j.1365-2559.2007.02883.x. PMID 18042066.