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Goitrogens are substances (whether in drugs, chemicals, or foods) that disrupt the production of thyroid hormones by interfering with iodine uptake in the thyroid gland. This triggers the pituitary to release TSH, which then promotes the growth of thyroid tissue, eventually leading to goiter.

Goitrogenic drugs and chemicals[edit]

Chemicals that have been shown to have goitrogenic effects include:

Goitrogenic foods[edit]

See also[edit]


  1. ^ Verhoeven DT, Verhagen H, Goldbohm RA, van den Brandt PA, van Poppel G (February 1997). "A review of mechanisms underlying anticarcinogenicity by brassica vegetables". Chem. Biol. Interact. 103 (2): 79–129. doi:10.1016/S0009-2797(96)03745-3. PMID 9055870. 
  2. ^ a b Vanderpas J (2006). "Nutritional epidemiology and thyroid hormone metabolism". Annu. Rev. Nutr. 26: 293–322. doi:10.1146/annurev.nutr.26.010506.103810. PMID 16704348. 
  3. ^ Erdogan MF (2003). "Thiocyanate overload and thyroid disease". BioFactors (Oxford, England) (Review). 19 (3-4): 107–11. doi:10.1002/biof.5520190302. PMID 14757960. 
  4. ^ Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.  8th edition.

External links[edit]