Gonadotropin-releasing hormone insensitivity

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Gonadotropin-releasing hormone insensitivity
Classification and external resources
eMedicine article/255152

Gonadotropin-releasing hormone (GnRH) insensitivity is a rare autosomal recessive genetic and endocrine syndrome which is characterized by inactivating mutations of the gonadotropin-releasing hormone receptor (GnRHR) and thus an insensitivity of the receptor to gonadotropin-releasing hormone (GnRH), resulting in a partial or complete loss of the ability of the gonads to synthesize the sex hormones. The condition manifests itself as isolated hypogonadotropic hypogonadism (IHH), presenting with symptoms such as delayed, reduced, or absent puberty, low or complete lack of libido, and infertility, and is the predominant cause of IHH when it does not present alongside anosmia.[1][2][3]

See also[edit]


  1. ^ Chevrier L, Guimiot F, de Roux N (October 2011). "GnRH receptor mutations in isolated gonadotropic deficiency". Molecular and Cellular Endocrinology. 346 (1-2): 21–8. PMID 21645587. doi:10.1016/j.mce.2011.04.018. 
  2. ^ Beate K, Joseph N, Nicolas de R, Wolfram K (2012). "Genetics of isolated hypogonadotropic hypogonadism: role of GnRH receptor and other genes". International Journal of Endocrinology. 2012: 147893. PMC 3249753Freely accessible. PMID 22229029. doi:10.1155/2012/147893. 
  3. ^ de Roux N (December 2006). "GnRH receptor and GPR54 inactivation in isolated gonadotropic deficiency". Best Practice & Research. Clinical Endocrinology & Metabolism. 20 (4): 515–28. PMID 17161329. doi:10.1016/j.beem.2006.10.005.