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Grand Isle may refer to:
In the United States:
- Grand Isle, a barrier island on the Gulf Coast, part of Jefferson Parish, Louisiana
- Grand Isle, Plaquemines Parish, Louisiana, a small community in the Mississippi River Delta
- Grand Isle, Maine
- Grand Isle, Vermont, a town in Vermont
- Grand Isle (island), an island in Vermont
- Grand Isle County, Vermont
- Grand Isle State Park (Vermont)
- Grand Island (disambiguation)
- Grande Île (disambiguation)
- Rail Car Grand Isle, an exhibition building at Shelburne Museum in Shelburne, Vermont
disambiguation page lists articles associated with the title Grand Isle.
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