Granulocyte-macrophage colony-stimulating factor receptor

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CSF2RA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSF2RA, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMR, SMDP4, colony stimulating factor 2 receptor alpha subunit, alphaGMR
External IDsOMIM: 425000 MGI: 1339754 HomoloGene: 48406 GeneCards: CSF2RA
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for CSF2RA
Genomic location for CSF2RA
BandXp22.33 and Yp11.2Start1,268,800 bp[1]
End1,310,381 bp[1]
RNA expression pattern
PBB GE CSF2RA 211286 x at fs.png

PBB GE CSF2RA 207085 x at fs.png

PBB GE CSF2RA 210340 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009970

RefSeq (protein)

NP_034100

Location (UCSC)Chr X: 1.27 – 1.31 MbChr 19: 61.22 – 61.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.[5]

It is associated with Surfactant metabolism dysfunction type 4.

Structure[edit]

The granulocyte-macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.[6] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.[7]

Signal transduction[edit]

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family.[7] This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198223 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059326 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nicola NA, Metcalf D (Aug 1985). "Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells". Journal of Cellular Physiology. 124 (2): 313–21. doi:10.1002/jcp.1041240222. PMID 3876343. 
  6. ^ McClure BJ, Hercus TR, Cambareri BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF (Feb 2003). "Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex". Blood. 101 (4): 1308–15. doi:10.1182/blood-2002-06-1903. PMID 12393492. 
  7. ^ a b Geijsen N, Koenderman L, Coffer PJ (Mar 2001). "Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family". Cytokine & Growth Factor Reviews. 12 (1): 19–25. doi:10.1016/S1359-6101(00)00019-8. PMID 11312115. 
  8. ^ Doyle SE, Gasson JC (Aug 1998). "Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5" (– Scholar search). Blood. 92 (3): 867–76. PMID 9680354. [dead link]

Further reading[edit]

External links[edit]