Grape seed extract

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Grape seed extract is an industrial derivative of whole grape seeds.

The extract contains proanthocyanidins.[1] In alternative medicine, grape seed extract is sold in dietary supplement form and claimed to have numerous health benefits which are not supported by sufficient medical evidence.[1]

Research and potential health effects[edit]

GSE is being investigated for its potential antibacterial properties.[2]

A meta-analysis of randomized controlled trials concluded that "grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or C-reactive protein levels."[3]

The US National Center for Complementary and Integrative Health reported that oral administration of grape seed extract was well tolerated in people over 8 weeks, although there are no studies yet indicating its effectiveness in treating diseases.[1]

Side effects may include itchy scalp; dizziness, headache, high blood pressure or nausea.[1]

See also[edit]


  1. ^ a b c d "Grape Seed Extract, Herbs at a Glance". US National Center for Complementary and Integrative Health, National Institutes of Health. 
  2. ^ Al-Habib A, Al-Saleh, E (2010). "Bactericidal effect of grape seed extract on methicillin-resistant Staphylococcus aureus (MRSA)". Journal of Toxicology Science. 35 (3): 357–64. PMID 20519844. 
  3. ^ Feringa, Harm H.H.; Laskey, Dayne A.; Dickson, Justine E.; Coleman, Craig I. (2011). "The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials". Journal of the American Dietetic Association. 111 (8): 1173–81. doi:10.1016/j.jada.2011.05.015. PMID 21802563.