Grape seed extract

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Grape seed extracts are industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid and phenolic procyanidins (also known as OPC or oligomeric procyanidins). The typical commercial opportunity of extracting grape seed constituents has been for chemicals known as polyphenols having antioxidant activity in vitro.

Possible health benefits[edit]

According to the American Cancer Society, "there is very little reliable scientific evidence available at this time that drinking red wine, eating grapes, or following the grape diet can prevent or treat cancer in people".[1]

A polyphenol contained in grape seeds is resveratrol, which is under study for its possible effect on cancer cell growth, proliferation or apoptosis, among other potential chemopreventive mechanisms.[2][3]

Other preliminary research on disease models[edit]

One clinical trial with adults having coronary disease or cardiac risk factors concluded that: "Four weeks of muscadine grape seed supplementation in subjects with increased cardiovascular risk did not produce a statistically significant increase in brachial flow-mediated vasodilation or a significant change in other biomarkers of inflammation, lipid peroxidation, or antioxidant capacity. However, the muscadine grape seed supplement did result in a significant increase in resting brachial diameter. The clinical significance of the effect on resting diameter is not yet established."[14]

A meta-analysis of randomized controlled trials concluded that "grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or C-reactive protein levels."[15]

The US National Center for Complementary and Integrative Health reported that oral administration of grape seed extract was well tolerated in people over 8 weeks.[16] In one completed clinical trial, grape seed extract did not alleviate the hardening of breast tissue in female patients undergoing radiation therapy to treat breast cancer.[17]

Dosage, precautions and interactions[edit]

Oral grape seed extract is used in capsules or tablets usually containing 50 mg or 100 mg. Insufficient scientific information is known, however, about how long-term use of grape seed extract might affect health or any disease.

Side-effects and cautions, other NCCIH advisories[edit]

  • In general, grape seed extract is well tolerated when taken by mouth, although it is better tolerated when encapsulated, as its taste is bitter. It has been used safely for up to 8 weeks in clinical trials[citation needed]
  • Side-effects most often include headache, a dry, itchy scalp, dizziness, or nausea[citation needed]
  • Interactions between grape seed extract and medicines or other supplements have not been carefully studied

Because of the possible action of proanthocyanidins on limiting platelet adhesion,[18] grape seed extract may act as a blood-thinner, increasing clotting time.

Aromatase inhibitor[edit]

Grape seed extract is also an aromatase inhibitor in vitro,[19] i.e. it may suppress the conversion of testosterone to estradiol.

See also[edit]


  1. ^ "Grapes". American Cancer Society. 1 November 2011. Retrieved August 2013. 
  2. ^ Kundu, Joydeb Kumar; Surh, Young-Joon (2008). "Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives". Cancer Letters 269 (2): 243–61. doi:10.1016/j.canlet.2008.03.057. PMID 18550275. 
  3. ^ Gao, N.; Budhraja, A.; Cheng, S.; Yao, H.; Zhang, Z.; Shi, X. (2009). "Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of c-Jun NH2-Terminal Kinase". Clinical Cancer Research 15 (1): 140–9. doi:10.1158/1078-0432.CCR-08-1447. PMC 2760842. PMID 19118041. Lay summaryBBC News (31 December 2008). 
  4. ^ Khanna, Savita; Venojarvi, Mika; Roy, Sashwati; Sharma, Nidhi; Trikha, Prashant; Bagchi, Debasis; Bagchi, Manashi; Sen, Chandan K (2002). "Dermal wound healing properties of redox-active grape seed proanthocyanidins". Free Radical Biology and Medicine 33 (8): 1089–96. doi:10.1016/S0891-5849(02)00999-1. PMID 12374620. 
  5. ^ Smullen, J.; Koutsou, G.A.; Foster, H.A.; Zumbé, A.; Storey, D.M. (2007). "The Antibacterial Activity of Plant Extracts Containing Polyphenols against Streptococcus mutans". Caries Research 41 (5): 342–9. doi:10.1159/000104791. PMID 17713333. 
  6. ^ Yahara, N; Tofani, I; Maki, K; Kojima, K; Kojima, Y; Kimura, M (2005). "Mechanical assessment of effects of grape seed proanthocyanidins extract on tibial bone diaphysis in rats" (PDF). Journal of musculoskeletal & neuronal interactions 5 (2): 162–9. PMID 15951633. 
  7. ^ Katiyar, Santosh K. (2008). "Grape seed proanthocyanidines and skin cancer prevention: Inhibition of oxidative stress and protection of immune system". Molecular Nutrition & Food Research. 52 Suppl 1: S71–6. doi:10.1002/mnfr.200700198. PMC 2562900. PMID 18384090. 
  8. ^ Baliga, Manjeshwar S.; Katiyar, Santosh K. (2006). "Chemoprevention of photocarcinogenesis by selected dietary botanicals". Photochemical & Photobiological Sciences 5 (2): 243–53. doi:10.1039/b505311k. PMID 16465310. 
  9. ^ Su, X; d'Souza, DH (2011). "Grape seed extract for control of human enteric viruses". Applied and environmental microbiology 77 (12): 3982–7. doi:10.1128/AEM.00193-11. PMC 3131668. PMID 21498749. 
  10. ^ Nair, Madhavan P; Kandaswami, Chithan; Mahajan, Supriya; Nair, Harikrishna N; Chawda, RAM; Shanahan, Thomas; Schwartz, Stanley A (2002). "Grape seed extract proanthocyanidins downregulate HIV- 1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells". Biological Research 35 (3–4): 421–31. doi:10.4067/S0716-97602002000300016. PMID 12462994. 
  11. ^ Al-Habib A, Al-Saleh, E (2010). "Bactericidal effect of grape seed extract on methicillin-resistant Staphylococcus aureus (MRSA)". Journal of Toxicology Science 357 (3): 357–64. PMID 20519844. 
  12. ^ Pan, Xinjuan; Dai, Yujie; Li, Xing; Niu, Nannan; Li, Wenjie; Liu, Fangli; Zhao, Yang; Yu, Zengli (2011). "Inhibition of arsenic induced-rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation". Toxicology and Applied Pharmacology 254 (3): 323–31. doi:10.1016/j.taap.2011.04.022. PMID 21605584. 
  13. ^ University of Maryland Medical Center - Grape Seed
  14. ^ Mellen, Philip B.; Daniel, Kurt R.; Brosnihan, K. Bridget; Hansen, Kim J.; Herrington, David M. (2010). "Effect of Muscadine Grape Seed Supplementation on Vascular Function in Subjects with or at Risk for Cardiovascular Disease: A Randomized Crossover Trial". Journal of the American College of Nutrition 29 (5): 469–75. doi:10.1080/07315724.2010.10719883. PMC 3313487. PMID 21504973. 
  15. ^ Feringa, Harm H.H.; Laskey, Dayne A.; Dickson, Justine E.; Coleman, Craig I. (2011). "The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials". Journal of the American Dietetic Association 111 (8): 1173–81. doi:10.1016/j.jada.2011.05.015. PMID 21802563. 
  16. ^ Grape Seed Extract, Herbs at a Glance, US National Center for Complementary and Integrative Health
  17. ^ Brooker, S; Martin, S; Pearson, A; Bagchi, D; Earl, J; Gothard, L; Hall, E; Porter, L; Yarnold, J (2006). "Double-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration". Radiotherapy and Oncology 79 (1): 45–51. doi:10.1016/j.radonc.2006.02.008. PMID 16546280. 
  18. ^ Shanmuganayagam, Dhanansayan; Beahm, Mark R.; Osman, Hashim E.; Krueger, Christian G.; Reed, Jess D.; Folts, John D. (2002). "Grape Seed and Grape Skin Extracts Elicit a Greater Antiplatelet Effect When Used in Combination than When Used Individually in Dogs and Humans". The Journal of Nutrition 132 (12): 3592–8. PMID 12468593. 
  19. ^ Kijima, I.; Phung, S; Hur, G; Kwok, SL; Chen, S (2006). "Grape Seed Extract is an Aromatase Inhibitor and a Suppressor of Aromatase Expression". Cancer Research 66 (11): 5960–7. doi:10.1158/0008-5472.CAN-06-0053. PMID 16740737. 

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