Grape seed extract
Grape seed extract (GSE) is an industrial derivative of whole grape seeds.
The extract contains proanthocyanidins. In alternative medicine GSE is sold in supplement form and claimed to have a wide range of health benefits which are not supported by sound medical evidence.
According to the American Cancer Society, "there is very little reliable scientific evidence available at this time that drinking red wine, eating grapes, or following the grape diet can prevent or treat cancer in people".
A meta-analysis of randomized controlled trials concluded that "grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or C-reactive protein levels."
The US National Center for Complementary and Integrative Health reported that oral administration of grape seed extract was well tolerated in people over 8 weeks.
- "Grapes". American Cancer Society. 1 November 2011. Retrieved August 2013.
- Al-Habib A, Al-Saleh, E (2010). "Bactericidal effect of grape seed extract on methicillin-resistant Staphylococcus aureus (MRSA)". Journal of Toxicology Science 357 (3): 357–64. PMID 20519844.
- Feringa, Harm H.H.; Laskey, Dayne A.; Dickson, Justine E.; Coleman, Craig I. (2011). "The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials". Journal of the American Dietetic Association 111 (8): 1173–81. doi:10.1016/j.jada.2011.05.015. PMID 21802563.
- Grape Seed Extract, Herbs at a Glance, US National Center for Complementary and Integrative Health
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