Greece is one of the oldest wine-producing regions in the world and among the first wine-producing territories in Europe. The earliest evidence of Greek wine has been dated to 6,500 years ago where wine was produced on a household or communal basis. In ancient times, as trade in wine became extensive, it was transported from end to end of the Mediterranean; Greek wine had especially high prestige in Italy under the Roman Empire. In the medieval period, wines exported from Crete, Monemvasia and other Greek ports fetched high prices in northern Europe.
The origins of wine-making in Greece go back 6,500 years and evidence suggesting wine production confirm that Greece is home to the second oldest known grape wine remnants discovered in the world and the world's earliest evidence of crushed grapes. As Greek civilization spread through the Mediterranean, wine culture followed. The Ancient Greeks introduced vines such as Vitis vinifera and made wine in their numerous colonies in Italy, Sicily, southern France, and Spain.
In 1937, a Wine Institute was established by the Ministry of Agriculture. During the 1960s, retsina suddenly became the national beverage. With rapidly growing tourism, retsina became associated worldwide with Greece and Greek wine. Greece's first Cabernet Sauvignon vineyard was planted in 1963. In 1971 and 1972, legislation established appellation laws.
- Protected Geographical Origins (P.D.O), i.e. an Appellation of Origin of Superior Quality
- Protected Geographical Identification (P.G.I.), i.e. a Quality wines of Origin
- Epitrapezios Oinos, i.e. a vin de table – Not certified wine in a region of Greece (that does not reflect the real wine quality)
- Amynteo (Amyndeon)
- Epanomi 
- Nea Anchialos
- Agiorgitiko ("St. George's grape") is a variety native to Nemea that grows mainly in the Peloponnese area, producing a soft, fruity red in many styles. Its sensory attributes are similar to Beaujolais Nouveau but, unlike its French counterpart, the St. George ages well for about five years.
- Kotsifali is a variety mainly grown on Crete. It is blended with Mandilaria or Syrah to enhance its color.
- Liatiko is a red variety native to Crete. It is characterised by flavors of red fruit and spices, and is deemed to be at its best when made as a sweet wine. Historically, the grape was used in blends with Mandilaria and Kotsifali to produce Malvasia, a highly regarded, sweet red wine that was widely exported by Venetian traders during the Middle Ages.
- Limnio, or Kalambaki, is an important red grape variety that is indigenous to the Aegean island of Lemnos and has been used in red wine production for more than 2000 years. As a varietal wine, Limnio is full-bodied, high in alcohol and very herbaceous, with a distinctive taste of bay leaves.
- Mandilaria, also known as amorgiano, is mainly cultivated on the islands of Rhodes and Crete. Wine from this grape is often very tannic and frequently blended with other grapes to soften the mouthfeel.
- Mavrodaphne, or "black laurel", is a variety that grows in the Peloponnese and the Ionian Islands. It is blended with the Black Corinth currant grape to produce a prized fortified dessert wine made in the Solera style.
- Mavroudi is one of the oldest Greek grape varieties and supposedly the one on which Odysseus got Polyphemus drunk. It is found in Thrace but also in central Greece and the Peloponnese
- Negoska is found in Northern Greece and also produces rose and red wines of carbonic maceration worth mentioning, with the expected aromas. blended into the PDO Goumenissa wine.
- Romeiko is a red grape generally found on Crete, most prominently in the region of Chania.
- Vertzami is a thick, dark-skinned grape variety, best known for single-varietal wines produced on the Ionian island of Lefkada. It is also grown in central Greece and Peloponnese, where it is often blended with other Greek wines, and Cyprus, where it is known as "Lefkas".
- Xinomavro ("sour black") is the predominant grape variety in Macedonia, centered on the town of Naousa. This variety has great aging potential with a palate reminiscent of tomatoes and olives, and a rich tannic character. It is often compared to Nebbiolo.
- Assyrtiko is a multi-purpose variety which maintains its acidity as it ripens. It is similar in character to Riesling, and is mostly island-based, being a native variety of the island of Santorini, whose old vines have been resistant to Phylloxera.
- Athiri is a lower acid variety and one of the most ancient. Originally from Santorini, it is now planted in Macedonia, Attica, and Rhodes.
- Debina is a white Greek wine grape primarily in the Zitsa region of Epirus. The grape's high acidity lends itself to sparkling wine production.
- Lagorthi is a variety mainly cultivated on high slopes (850 meters) in the Peloponnese. The grape produces a very malic and fruity wine.
- Malagousia is a grape growing mainly in Macedonia, with a special aroma leading to elegant full bodied wines, with medium-plus acidity and exciting perfumed aromas.
- Moschofilero is a Blanc de gris variety from the AOC region of Mantineia, in Arcadia in the Peloponnese. Its wines offer a crisp and floral character in both still and sparkling styles.
- Robola is most grown in the mountainous vineyards of the Ionian Island of Cephalonia. It has a smokey mineral and lemony character, excellently complementing seafood.
- Roditis (the "pink" or "rose" grape) is a grape that is very popular in Attica, Macedonia, Thessaly, and the Peloponnese. This variety produces elegant, light white wines with citrus flavors.
- Savatiano (the "Saturday" grape) is the predominant white grape in the region of Attica, where it displays excellent heat resistance and shows a distinct floral and fruity aroma when cold fermentation is practised. When fermented without cooling, it makes retsina or rustic unresinated wines that complement Mediterranean dishes well.
- Vidiano is a white grape indigenous to Crete. It has complex aromas of peach, apricot, melon, honey and herbs, along with moderate acidity. The grape is difficult to cultivate and is grown in small scale, chiefly around Rethymno and Heraklion.
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- 6,500-year-old Mashed grapes found World’s earliest evidence of crushed grapes
- 6500-year-old Mashed grapes found Archived 2007-03-20 at the Wayback Machine
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