|Born||August 7, 1948|
|Alma mater||Princeton University|
Member of the U.S. National Academy of Sciences
Member of the U.S. National Academy of Medicine
Member of the American Academy of Arts and Sciences
Member of the American Philosophical Society
|Institutions||Brigham and Women's Hospital|
Weill Cornell Medical College
Wayne State University
Max Planck Institute
University of Oxford
|Thesis||Structural studies of triose phosphate isomerase. (1974)|
|Doctoral advisor||David Chilton Phillips|
Gregory A. Petsko (born August 7, 1948) is an American biochemist and member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. He is currently at the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital. He formerly had an endowed professorship in Neurology and Neuroscience at Weill Cornell Medical College and is still an adjunct professor of Biomedical Engineering at Cornell University, and Professor Emeritus in Biochemistry and Chemistry at Brandeis University.
As of 2019 Petsko's research interests are understanding the biochemical bases of neurological diseases like Alzheimer's, Parkinson's, and ALS, discovering drugs (especially by using structure-based drug design) and biologics, especially gene therapy, that could therapeutically affect those biochemical targets, and seeing any resulting clinical candidates tested in humans. He has made key contributions to the fields of protein crystallography, biochemistry, biophysics, enzymology, and neuroscience.
Petsko was an undergraduate at Princeton University. He received a Rhodes Scholarship, and obtained his doctorate from the University of Oxford supervised by Professor Sir David Chilton Phillips (later Lord Phillips of Ellesmere), studying the enzyme triosephosphate isomerase. He did a brief postdoctoral fellowship in Paris with Pierre Douzou, studying enzymology at low temperatures. In 1995 he did a sabbatical at the University of California at San Francisco with Ira Herskowitz, where he learned yeast genetics and molecular biology.
Petsko's independent academic career included stints at Wayne State University, the Massachusetts Institute of Technology, the Max Planck Institute for Medical Research in Heidelberg, and, from 1991 until 2012, Brandeis University, where he was Professor of Biochemistry and of Chemistry and Director of the Rosenstiel Basic Medical Sciences Research Center. He is Past-President of the American Society for Biochemistry and Molecular Biology. In April 2010, he was elected to the American Philosophical Society. In 2012, he announced that he was moving to Weill Cornell Medical College in New York City, where his wife, Laurie Glimcher, had been appointed Dean. He was appointed at Weill Cornell Medical College as the Director of the Helen and Robert Appel Alzheimer's Disease Research Institute and the Arthur J. Mahon Professor of Neurology and Neuroscience in the Feil Family Brain and Mind Research Institute, at Cornell University as Adjunct Professor of Biomedical Engineering, and retained an appointment at Brandeis University as Gyula and Katica Tauber Professor of Biochemistry and Chemistry, Emeritus. His wife was named President and CEO of the Dana-Farber Cancer Institute in October 2016, and in January 2019 he followed her back to Boston, assuming his present position at the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital.
As of 2019 Petsko's research interests are understanding the biochemical bases of neurological diseases like Alzheimer's, Parkinson's, and ALS, discovering drugs (especially by using structure-based drug design) that could therapeutically affect those biochemical targets, and seeing any resulting drug candidates tested in humans.
Petsko's past research interests have been in protein crystallography and enzymology. He is co-author with Dagmar Ringe of Protein Structure and Function. He was also the author of a monthly column in Genome Biology modelled after an amusing column in Current Biology penned by Sydney Brenner. Petsko is best known for his collaborative work with Dagmar Ringe, in which they used X-ray crystallography to solve important problems in protein function including protein dynamics as a function of temperature and problems in mechanistic enzymology.
- Tom Alber and John Kuriyan, professors at University of California, Berkeley
- Barry Stoddard and Roland Strong, faculty at Fred Hutchinson Cancer Research Center
- Ilme Schlichting, department head at Max Planck Institute for Medical Research
- Ann Stock, professor at the Howard Hughes Medical Institute and Rutgers
- Steven Almo, professor at Albert Einstein College of Medicine
- Axel Brunger, professor at Stanford University
- Elias Lolis, professor at Yale University
- Dennis Vitkup, professor at Columbia University
- Charles Brenner, department head at University of Iowa
- Karen Allen, professor at Boston University
- Lynne Howell, professor at University of Toronto
- David Rose, professor at University of Waterloo
- and Stephen Burley formerly of SGX Pharmaceuticals and now head of the Protein Data Bank
|Scholia has an author profile for Gregory Petsko.|
- Tate Herbert for The Justice November 13, 2012 Petsko set to leave University for New York City in 2014
- Weill Cornell Newsroom. April 16, 2014 No Stone Unturned: Interview with Gregory Petsko
- Petsko Laboratory Homepage
- Columbia University Newsroom. April 20, 2014 'Chaperone' compounds offer new approach to Alzheimer's treatment
- List of publications from Microsoft Academic
- Petsko, Gregory A. (2008). Protein Structure and Function (Primers in Biology). Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-955684-9.
- Petsko, G. A. (2000). "The grail problem". Genome Biology. 1 (1): comment002.comment001–comment002.comment001. doi:10.1186/gb-2000-1-1-comment002. PMC 138819. PMID 11104515.
- Petsko, G. A. (2012). "A case of the flu". Genome Biology. 13 (2): 146. doi:10.1186/gb-2012-13-2-146. PMC 3334562. PMID 22364112.
- Brenner, S. (2002). "The worm's turn". Current Biology. 12 (21): R713. doi:10.1016/s0960-9822(02)01241-1. PMID 12419193.
- Frauenfelder, H.; Petsko, G. A.; Tsernoglou, D. (1979). "Temperature-dependent X-ray diffraction as a probe of protein structural dynamics". Nature. 280 (5723): 558–563. doi:10.1038/280558a0. PMID 460437.
- Schlichting, I.; Berendzen, J.; Chu, K.; Stock, A. M.; Maves, S. A.; Benson, D. E.; Sweet, R. M.; Ringe, D.; Petsko, G. A.; Sligar, S. G. (2000). "The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution". Science. 287 (5458): 1615–1622. doi:10.1126/science.287.5458.1615. PMID 10698731.
- Karplus, M.; Petsko, G. A. (1990). "Molecular dynamics simulations in biology". Nature. 347 (6294): 631–639. doi:10.1038/347631a0. PMID 2215695.