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Gristle may refer to:
- Cartilage, when present in meat
- Throbbing Gristle, an English avant-garde music and visual arts group
- Gristle (G.I. Joe), a fictional villain in the G.I. Joe universe
- Puppy Gristle, a 2002 album by Skinny Puppy
- The House of Gristle, a 1994 British television series
- Radio Free Gristle, a CD by Greg Koch
disambiguation page lists articles associated with the title Gristle.
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