Growth hormone 2

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GH2
Protein GH2 PDB 1a22.png
Identifiers
Aliases GH2, GH-V, GHL, GHV, hGH-V, GHB2, Growth hormone 2
External IDs HomoloGene: 128757 GeneCards: GH2
RNA expression pattern
PBB GE GH2 211508 s at fs.png

PBB GE GH2 206195 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022558
NM_002059
NM_022556
NM_022557

n/a

RefSeq (protein)

NP_002050
NP_072050
NP_072051
NP_072052

n/a

Location (UCSC) Chr 17: 63.88 – 63.88 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Growth hormone variant is a protein that in humans is encoded by the GH2 gene.[2][3]

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones, playing an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.[3]

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Further reading[edit]