GNAS Identifiers Aliases , AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, POH, SCG6, SgVI, GNAS complex locus, PITA3 GNAS External IDs OMIM: 139320 MGI: 95777 HomoloGene: 55534 GeneCards: GNAS
Gene location (Mouse) Chr. Chromosome 2 (mouse)  Band 2 H4|2 97.89 cM Start 174,284,320 bp  End 174,346,744 bp  Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 20: 58.84 – 58.91 Mb Chr 2: 174.28 – 174.35 Mb PubMed search   Wikidata
G ( s alpha subunit G, αs G, or sα G) is a s protein heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase. It is one of the three main families of G proteins: G/G αi αo, G, and G αq αs. A mnemonic for remembering this subunit is to look at the first letter (G  = αs Adenylate Cyclase stimulator). In humans it is encoded by the GNAS complex locus.
Receptors [ edit ]
G protein-coupled receptors that couple to this kind of G-protein include:
Function [ edit ]
The general function of G
s is to activate adenylyl cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of G s are thus found in function of cAMP-dependent protein kinase.
It provides a step in
signal transduction. Amplification of the signal occurs for instance because the receptor activates several G s. However, each G  s activates only one adenylate cyclase.
See also [ edit ]
References [ edit ]
^ a b c
GRCh38: Ensembl release 89: ENSG00000087460 - Ensembl, May 2017
^ a b c
GRCm38: Ensembl release 89: ENSMUSG00000027523 - Ensembl, May 2017
"Human PubMed Reference:".
"Mouse PubMed Reference:".
Ellis C, Nature Reviews Drug Discovery GPCR Questionnaire Participants (July 2004). "The state of GPCR research in 2004". Nature Reviews. Drug Discovery. 3 (7): 575, 577–626. doi: 10.1038/nrd1458. PMID 15272499.
^ a b
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia AS, White LE, eds. (2007). Neuroscience (4th ed.). New York: W. H. Freeman. p. 155. ISBN . 978-0-87893-697-7
External links [ edit ]