Gs alpha subunit

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Protein GNAS PDB 1azs.png
AliasesGNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, POH, SCG6, SgVI, GNAS complex locus, PITA3
External IDsOMIM: 139320 MGI: 95777 HomoloGene: 55534 GeneCards: GNAS
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for GNAS
Genomic location for GNAS
Band20q13.32Start58,839,718 bp[1]
End58,911,192 bp[1]
RNA expression pattern
PBB GE GNAS 200780 x at fs.png

PBB GE GNAS 200981 x at fs.png

PBB GE GNAS 211858 x at fs.png
More reference expression data
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 20: 58.84 – 58.91 MbChr 2: 174.28 – 174.35 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The Gs alpha subunit (Gαs, G, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase. It is one of the three main families of G proteins: Gαi/Gαo, Gαq, and Gαs.[5] A mnemonic for remembering this subunit is to look at the first letter (Gαs = Adenylate Cyclase stimulator). In humans it is encoded by the GNAS complex locus.


The G protein-coupled receptors that couple to this kind of G-protein include:


The general function of Gs is to activate adenylyl cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs are thus found in function of cAMP-dependent protein kinase.

It provides a step in signal transduction. Amplification of the signal occurs for instance because the receptor activates several Gs.[6] However, each Gs activates only one adenylate cyclase.[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087460 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027523 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Ellis C, Nature Reviews Drug Discovery GPCR Questionnaire Participants (July 2004). "The state of GPCR research in 2004". Nature Reviews. Drug Discovery. 3 (7): 575, 577–626. doi:10.1038/nrd1458. PMID 15272499.
  6. ^ a b Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia AS, White LE, eds. (2007). Neuroscience (4th ed.). New York: W. H. Freeman. p. 155. ISBN 978-0-87893-697-7.

External links[edit]