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Guadalupe River may refer to:
- Guadalupe River (California)
- Guadalupe River (New Mexico), a tributary of the Jemez River
- Guadalupe River (Texas)
- Guadalupe River (Spain), in southern Spain
- Guadalupe River State Park, a Texas state park located on a section of the Guadalupe River in Kendall and Comal Counties, northwest of Bulverde, Texas United States
- Guadalope River, in northern Spain
|This disambiguation page lists articles about distinct geographical locations with the same name.
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