Guanidinoacetate kinase

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guanidinoacetate kinase
EC number
CAS number 9026-60-2
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a guanidinoacetate kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + guanidinoacetate ADP + phosphoguanidinoacetate

Thus, the two substrates of this enzyme are ATP and guanidinoacetate, whereas its two products are ADP and phosphoguanidinoacetate.

Guanidinoacetate kinase belongs to the family of transferases, specifically those that transfer phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. The systematic name of this enzyme class is ATP:guanidinoacetate N-phosphotransferase. This enzyme is also called glycocyamine kinase. This enzyme participates in arginine and proline metabolism.


  • HOBSON GE, REES KR (1957). "The annelid phosphokinases". Biochem. J. 65 (2): 305–7. PMC 1199870Freely accessible. PMID 13403909. 
  • Pradel LA; Kassab R; Conlay C; Nguyen Van Thoai (1968). "[Properties and amino acid composition of purified ATP: guanidinoacetate phosphotransferase]". Biochim. Biophys. Acta. 154 (2): 305–14. PMID 5637051. doi:10.1016/0005-2795(68)90044-5. 
  • Pradel LA, Kassab R, Thoai NV (1964). "Sur l'acide adenosine-triphosphorique:guanidoacetate phosphotransferase". Biochim. Biophys. Acta. 81: 86–95. doi:10.1016/0926-6569(64)90338-4. 
  • Thoai NV (1957). "Sur la taurocyamine et la glycocyamine phosphokinase". Bull. Soc. Chim. Biol. 39: 197–208.