Guanidinobutyrase

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guanidinobutyrase
Identifiers
EC number3.5.3.7
CAS number9013-69-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a guanidinobutyrase (EC 3.5.3.7) is an enzyme that catalyzes the chemical reaction

4-guanidinobutanoate + H2O 4-aminobutanoate + urea

Thus, the two substrates of this enzyme are 4-guanidinobutanoate and H2O, whereas its two products are 4-aminobutanoate and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is 4-guanidinobutanoate amidinohydrolase. Other names in common use include gamma-guanidobutyrase, 4-guanidinobutyrate amidinobutyrase, gamma-guanidinobutyrate amidinohydrolase, G-Base, GBH, and guanidinobutyrate ureahydrolase. This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, manganese.

References[edit]

  • Mora J, Tarrab R, Martuscelli J, Soberon G (1965). "Characteristics of arginases from ureotelic and non-ureotelic animals". Biochem. J. 96 (3): 588–94. doi:10.1042/bj0960588. PMC 1207192. PMID 5862400.
  • Nguyen Van Thoai Thome-Beau F, Olomucki A (1966). "[Induction and specificity of enzymes of the new catabolic arginine pathway]". Biochim. Biophys. Acta. 115 (1): 73–80. doi:10.1016/0304-4165(66)90050-x. PMID 5936244.
  • Yorifuji T, Kato M, Kobayashi T, Ozaki S, Ueno S (1980). "4-Guanidinobutyrate amidinohydrolase from Pseudomonas sp ATCC 14676: purification to homogeneity and properties". Agric. Biol. Chem. 44 (5): 1127–1134. doi:10.1271/bbb1961.44.1127.
  • K; Kobayashi, Toru; Tabuchi, Akira; Shiritani, Yoshinori; Yonaha, Kazuo (1983). "Distribution of amidinohydrolases among Pseudomonas and comparative studies of some purified enzymes by one-dimensional peptide mapping". Agric. Biol. Chem. 47 (12): 2825–2830. doi:10.1271/bbb1961.47.2825.