3D model (JSmol)
|Molar mass||g·mol−1 383.532|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Endocannabinoid Reuptake Inhibition
Guineensine seems to potently inhibit the cellular reuptake of anandamide and 2-arachidonoylglycerol (EC50 = 290 nM).  This causes an increase in the activity of the two neurotransmitters which are classified as endogenous cannabinoids.
Guineesine can dose-dependently produce cannabimimetic effects which are indicated by potent catatonic, analgesic, hypo-locomotive and hypo-thermic effects. In addition, the analgesic and catatonic effects were reversed by the cannabinoid receptor type 1 (CB1) inverse agonist rimonabant.
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