GyrA RNA motif

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gyrA RNA motif
GyrA-1-RNA.svg
Consensus secondary structure of gyrA RNAs
Identifiers
Symbol gyrA RNA
Rfam RF01740
Other data
RNA type Cis-regulatory element
Domain(s) Pseudomonadales

The gyrA RNA motif is a conserved RNA structure identified by bioinformatics.[1] The RNAs are present in multiple species of bacteria within the order Pseudomonadales. This order contains the genus Pseudomonas, which includes the opportunistic human pathogen Pseudomonas aeruginosa and Pseudomonas syringae, a plant pathogen.

gyrA RNAs are always found in the presumed 5' untranslated regions of gyrA genes, which encodes a protein forming a subunit of a DNA gyrase. Resistance to the antibiotic ciprofloxacin in Pseudomonas is often achieved via mutations in the gyrA gene.[2] Because of its positioning, the gyrA RNA motif was hypothesized to be a cis-regulatory element acting up the downstream gyrA genes. However, gyrA was previously regarded as a gene whose level of expression is consistent in a wide variety of growth conditions.[3]

References[edit]

  1. ^ Weinberg Z, Wang JX, Bogue J, et al. (March 2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes". Genome Biol. 11 (3): R31. PMC 2864571Freely accessible. PMID 20230605. doi:10.1186/gb-2010-11-3-r31. 
  2. ^ Bonomo RA, Szabo D (September 2006). "Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa". Clin. Infect. Dis. 43 Suppl 2: S49–56. PMID 16894515. doi:10.1086/504477. 
  3. ^ Vencato M, Tian F, Alfano JR, et al. (November 2006). "Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A". Mol. Plant Microbe Interact. 19 (11): 1193–206. PMID 17073302. doi:10.1094/MPMI-19-1193. 

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