H. Lee Moffitt Cancer Center & Research Institute
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|Type||non-profit cancer treatment and research center|
|Affiliation||National Cancer Institute-designated Comprehensive Cancer Center|
|Dean||CEO Alan List, MD|
H. Lee Moffitt Cancer Center & Research Institute is a nonprofit cancer treatment and research center located in Tampa, Florida. Established in 1981 by the Florida Legislature, the hospital opened in October 1986, on the University of South Florida campus. Moffitt is the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida  In 2018, U.S. News & World Report ranked Moffitt Cancer Center as the No. 8 cancer hospital in the nation.
Funding for construction of the initial $70 million facility came primarily from the state of Florida's cigarette tax, while the momentum to create the center came from a cadre of legislators, physicians, educators, and business leaders who envisioned a new dimension of cancer care and research in Florida.
In late 1978, H. Lee Moffitt, a Florida State Representative, recognized the need for a comprehensive cancer center within the state after several friends died from cancer. An excellent negotiator, Moffitt put his plan into motion by first proposing the idea to Dr. Hollis Boren, then dean of the University of South Florida College of Medicine. Over lunch at the Tampa Club, Moffitt proposed his idea. By dessert, Boren has signed on. "Out of that discussion came plans for a plug-shaped, multilevel cancer research teaching hospital to be built a short walk away from the USF clinics," The Tampa Times reported on February 5, 1979. Moffitt and Boren had gathered information about the need for a comprehensive cancer center, the article said, and the need was great.
Moffitt sought community support and convinced the State Legislature to fund the facility. During the center's planning phase, consultants associated with NCI-designated Cancer Centers were retained to ensure that the finished facility would be as technologically advanced and as efficiently designed as possible.
Groundbreaking ceremonies took place in January 1983. The center was incorporated in the spring of 1984 and was named for H. Lee Moffitt, then Speaker of the State House of Representatives. The building was dedicated in October 1986 and admitted its first patients that same month.
In 1990, the acquisition of the Research Center building across from the Cancer Center enhanced the recruitment of scientists, clinicians, and support staff, and expanded Moffitt's vision beyond the original structure. The Moffitt Research Center became the focal point for basic and translational cancer research with the overriding goal to produce discoveries that could be translated quickly from the bench to the patient's bedside. The Florida Legislature allocated $12 million for renovation and equipment for this 100,000-square-foot (9,300 m2) structure, and the Moffitt Research Center became fully operational in 1995. In 1999, 48,000 square feet (4,500 m2) of basic research lab space was added to the Moffitt Research Center at a cost of $11 million to house the growing need for additional scientists.
On June 10, 1998, in a ceremonial signing at Moffitt, Florida Governor Lawton Chiles approved a legislative initiative to fund construction of the Moffitt Tower Project, which opened in April 2003, adding more than 350,000 square feet (33,000 m2) of new space. This expansion includes the Vincent A. Stabile Research Building, eponymously named in recognition of the largest private donation ever made to the Cancer Center. The new construction also includes an expansion of the Moffitt Clinic. In addition to new research laboratories, which nearly double the cancer center's research capabilities, the new facilities include a digital imaging center, and a new infusion center.
In 1991, John Ruckdeschel, M.D., assumed the position of Center Director, President and CEO. Under Ruckdeschel's leadership, Moffitt became a National Cancer Institute (NCI) Comprehensive Cancer Center. In 2006, the NCI renewed Moffitt's Cancer Center Support Grant for another five years. Currently Moffitt receives more than $50 million annually in peer-reviewed grant monies.
In 2002, Ruckdeschel stepped down, and William Dalton, Ph.D., M.D., became Moffitt's third President, CEO and Center Director.
In 2009, the University of South Florida and Moffitt were awarded $6 million in federal grant money to create the Center for Equal Health, a five-year partnership focused on addressing issues of cancer health disparities.
Scientific programs include Molecular Oncology, Drug Discovery, Immunology, Experimental Therapeutics, Computational Biology of Cancer, Health Outcomes and Behavior and Risk Assessment, Detection and Intervention. It also serves as the site for the Bill and Beverly Young National Functional Genomics Center, funded by the U.S. Department of Defense.
On June 24, 2011, Moffitt Cancer Center opened the first blood and marrow transplant (BMT) clinic in Puerto Rico.
On July 1, 2011, Moffitt Cancer Center opened a new 50,000-square-foot satellite facility at International Plaza. The building replaced Moffitt's former outpatient center at Tampa General Hospital.
In July 2012, William Dalton, Ph.D., M.D., became the CEO of M2Gen and Moffitt's new Personalized Medicine Institute. Alan List, M.D., who previously served as Moffitt's executive vice president/physician-in-chief and president of the Moffitt Medical Group, succeeded Dalton as CEO and president. Thomas Sellers, Ph.D., assumed the role of center director.
In February 2013, Moffitt began construction of a $74.2 million outpatient facility on the cancer center's 30-acre property on N McKinley Drive, about a mile from Moffitt's main campus.
In November 2015, Moffitt opens the McKinley Outpatient Center. The six-story, 207,000-square-foot facility at 10920 N McKinley Drive is located about a mile from the main campus. Services on the site include the skin and breast cancer clinics, four operating rooms, an imaging suite, research labs, space for blood draws and a Publix pharmacy.
In July 2017, Moffitt and Memorial Healthcare announce a partnership to establish a comprehensive Blood and Marrow Transplant Cellular Therapy Program for South Florida residents. The alliance brings the renowned cancer center's access to research, clinical trials, and comprehensive treatment to leukemia, lymphoma and multiple myeloma patients.
Research and Treatment
Through clinical trials, Jeffrey Weber, M.D., Ph.D., director of the Donald A. Adam Comprehensive Melanoma Research Center at Moffitt, and researchers at Moffitt Cancer Center discovered two monotherapy drugs – Mekinist (trametinib) and Tafinlar (dabrafenib) – can be safely combined to overcome or delay treatment resistance for a large percentage of melanoma patients with a specific gene mutation. Approved by the FDA in January 2014, Mekinist in combination with Tafinlar is one of the biggest advancements in melanoma treatment in the past 30 years.
In August 2011, the U.S. Food and Drug Administration (FDA) approved the drug vemurafenib (Zelboraf) for metastatic melanoma patients who test positive for a specific gene mutation. Moffitt Cancer Center conducted a registration trial using the drug manufactured by Genentech, a member of the Roche Group.
Dr. Anna Giuliano, director of Moffitt's Center for Infection Research in Cancer, led two studies on human papillomavirus (HPV) infection in men. Her work strengthened the Food & Drug Administration (FDA) recommendation for boys and men to receive HPV vaccinations and provided useful data for the development of realistic cost-effectiveness models for male HPV vaccination internationally.
In September 2014, a new cancer immunotherapy for melanoma patients called Keytruda became the first anti-PD-1 (programmed death receptor-1) therapy approved in the United States. Jeffrey Weber, M.D., Ph.D., director of the Donald A. Adam Comprehensive Melanoma Research Center of Excellence at Moffitt, was one of the lead investigators of the clinical trial which led to the drug receiving breakthrough status from the FDA.
In January 2016, researchers at Moffitt teamed up with the state of Florida in a study to see if making fruits and vegetables available to children who otherwise may not have them readily available can decrease their risk of cancer.
In October 2017, the Food and Drug Administration announced the approval of Yescarta™, a revolutionary new immunotherapy for adult patients with diffuse large B cell lymphoma, a form of non-Hodgkin's lymphoma. Yescarta is a Chimeric Antigen Receptor (CAR) T cell therapy, also known as CAR-T. Moffitt Cancer Center's Frederick Locke, M.D., is the co-lead investigator of the pivotal ZUMA-1 clinical trial that tested the new therapy, which is manufactured by Kite, a Gilead company.
Moffit Cancer Center is located on the campus of the University of South Florida in north Tampa. The center includes the hospital, Muriel Rothman Building (clinic), Vincent A. Stabile Research Building and the Moffitt Research Center.
Moffitt at International Plaza is a 50,000-square-foot full service outpatient facility near Tampa International Airport. The facility includes physician office visits, infusion services, radiation and radiology.
Moffitt Cancer Center Screening and Prevention, located in north Tampa, provides services aimed at the prevention and early detection of cancer.
The Richard M. Schulze Family Foundation Outpatient Center at McKinley Campus, 10920 N. McKinley Drive, includes the breast and skin cancer clinics, infusion center, research labs and four surgery suites.
Moffitt Malignant Hematology & Cellular Therapy at Memorial Healthcare System, 801 N. Flamingo Road, Pembroke Pines, FL, provides a comprehensive Blood and Marrow Transplant Cellular Therapy Program for South Florida residents. 
- From 1999 to 2018, Moffitt has been ranked one of "America's Best Hospitals" for cancer by U.S. News & World Report.
- In 2014, Becker's Hospital Review includes Moffitt in the 100 Accountable Care Organizations to Know.
- In 2015, Moffitt earned a Magnet designation for nursing excellence, granted by the American Nurses Credentialing Center (ANCC), the credentialing body of the American Nurses Association.[verification needed]
- In 2015, Becker's Hospital Review recognizes Moffitt's President and CEO Dr. Alan List in its "100 Physician Leaders of Hospitals and Health Systems." 
- Moffitt Cancer Center was named 2017 Nonprofit of the Year by the Tampa Bay Business Journal. Moffitt was also recognized as the category winner in the Health & Human Services category.
- In 2018, Moffitt was named LGBTQ Healthcare Equality Leader by the Human Rights Campaign Foundation.  The cancer center was also named one of Working Mother Magazine’s 100 Best Companies for 10th time.
- "About Us - Our Story". Moffitt Cancer Center.
- "Cancer Centers". American Cancer Society.
- "National Cancer Institute - Moffitt Cancer Center". American Cancer Society.
- "Best Hospitals for Cancer". U.S. News & World Report. 2018.
- "Article". The Tampa Times. February 5, 1979.
- "About Us - Our Story". Moffitt Cancer Center.
- Moffitt creates partnership with the University of Florida
- UF announces partnership with Moffitt
- medialnewstoday.com reference
- Center for Equal Health
- USF, Moffitt get grant for minority health center
- USF Health Affiliated Hospitals
- Moffitt Training Sites
- Tampa cancer center opens first bone marrow transplant clinic in Puerto Rico
- New Moffitt facility near International Plaza means convenience, technology for cancer patients
- Moffitt Cancer Center project is the Rx for a sluggish economy
- Small touches for patients are the pride of Moffitt's new outpatient center
- QUINN CHAMBERLAIN, ALEXIS (12 July 2011). "Moffitt Cancer Clinic Opens Near International Plaza". 83Degrees. Retrieved 2017-09-25.
- "Moffitt Cancer Center Prevention Research". Moffitt Cancer Center. Archived from the original on 2014-10-06. Retrieved 2017-09-25.
- Manning, Margie (2 November 2015). "Inside Moffitt's new outpatient center". www.bizjournals.com. Retrieved 2017-09-25.
- "H. Lee Moffitt Cancer Center and Research Institute, Nationally Ranked in 2 Specialties". usnews.com. Archived from the original on 2012-09-16. Retrieved 25 September 2017.
- Gordon, Molly Gamble, Heather Punke, Ayla Ellison, Akanksha Jayanthi and Dani. "100 accountable care organizations to know | 2014". www.beckershospitalreview.com. Retrieved 2017-09-25.
- "Archived copy". Archived from the original on 2015-04-04. Retrieved 2015-04-06.CS1 maint: Archived copy as title (link)
- Staff. "100 physician leaders of hospitals and health systems 2015". www.beckershospitalreview.com. Retrieved 2017-09-25.