H2AFB1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
H2AFB1
Identifiers
Aliases H2AFB1, H2A.Bbd, H2A histone family member B1
External IDs MGI: 3642445 HomoloGene: 129517 GeneCards: H2AFB1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017990

NM_001102665

RefSeq (protein)

NP_001017990

n/a

Location (UCSC) Chr X: 154.88 – 154.89 Mb Chr X: 117.01 – 117.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2A-Bbd type 1 also known as H2A Barr body-deficient is a histone protein variant that in humans is encoded by the H2AFB1 gene (H2A histone family, member B1).[3]

Function[edit]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene.[3]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.