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H2A histone family, member J
Protein H2AFJ PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols H2AFJ ; H2AJ
External IDs MGI3606192 HomoloGene128575 GeneCards: H2AFJ Gene
Species Human Mouse
Entrez 55766 232440
Ensembl ENSG00000246705 ENSMUSG00000060032
UniProt Q9BTM1 Q8R1M2
RefSeq (mRNA) NM_018267 NM_177688
RefSeq (protein) NP_808760 NP_808356
Location (UCSC) Chr 12:
14.77 – 14.78 Mb
Chr 6:
136.81 – 136.81 Mb
PubMed search [1] [2]

Histone H2A.J is a protein that in humans is encoded by the H2AFJ gene.[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member.[1]


Further reading[edit]