HAMP

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This article is about the protein that is encoded by the HAMP gene. For other uses, see HAMP (disambiguation).
HAMP
Protein HAMP PDB 1m4f.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
External IDs OMIM: 606464 HomoloGene: 81623 GeneCards: HAMP
RNA expression pattern
PBB GE HAMP 220491 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021175

n/a

RefSeq (protein)

NP_066998.1

n/a

Location (UCSC) Chr 19: 35.28 – 35.29 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Hepcidin is a protein that in humans is encoded by the HAMP gene.[2][3][4]

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K (Nov 2000). "LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity". FEBS Lett. 480 (2–3): 147–50. doi:10.1016/S0014-5793(00)01920-7. PMID 11034317. 
  3. ^ Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O (May 2001). "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload". J Biol Chem. 276 (11): 7811–9. doi:10.1074/jbc.M008923200. PMID 11113132. 
  4. ^ a b "Entrez Gene: HAMP hepcidin antimicrobial peptide". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.