HAS1

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HAS1
Identifiers
Aliases HAS1, HAS, hyaluronan synthase 1
External IDs MGI: 106590 HomoloGene: 1165 GeneCards: HAS1
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for HAS1
Genomic location for HAS1
Band 19q13.41 Start 51,713,112 bp[1]
End 51,723,994 bp[1]
RNA expression pattern
PBB GE HAS1 207316 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001297436
NM_001523

NM_008215

RefSeq (protein)

NP_001284365
NP_001514

NP_032241

Location (UCSC) Chr 19: 51.71 – 51.72 Mb Chr 19: 17.84 – 17.86 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hyaluronan synthase 1 is an enzyme that in humans is encoded by the HAS1 gene.[5][6]

Structure[edit]

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-transporter into the extracellular space.[7]

Function[edit]

It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105509 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003665 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154. 
  6. ^ a b "Entrez Gene: HAS1 hyaluronan synthase 1". 
  7. ^ Schulz T, Schumacher U, Prehm P (July 2007). "Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP". J. Biol. Chem. 282 (29): 20999–1004. doi:10.1074/jbc.M700915200. PMID 17540771. 

Further reading[edit]