HAS3

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HAS3
Identifiers
Aliases HAS3
External IDs MGI: 109599 HomoloGene: 68461 GeneCards: 3038
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199280
NM_005329
NM_138612

NM_008217

RefSeq (protein)

NP_001186209.1
NP_005320.2
NP_619515.1

NP_032243.2

Location (UCSC) Chr 16: 69.11 – 69.12 Mb Chr 8: 106.87 – 106.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.[3][4][5]

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154. 
  4. ^ Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem. 272 (14): 8957–61. doi:10.1074/jbc.272.14.8957. PMID 9083017. 
  5. ^ a b "Entrez Gene: HAS3 hyaluronan synthase 3". 

Further reading[edit]