HBE1

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HBE1
Protein HBE1 PDB 1a9w.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HBE1, HBE, hemoglobin subunit epsilon 1
External IDs MGI: 96024 HomoloGene: 110794 GeneCards: HBE1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005330

NM_008219

RefSeq (protein)

NP_005321
NP_005321.1

NP_032245

Location (UCSC) Chr 11: 5.27 – 5.51 Mb Chr 7: 103.84 – 103.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene.[3]

Function[edit]

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilongamma-Ggamma-Adeltabeta - 3'.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. PMID 2649166. 
  4. ^ "Entrez Gene: HBE1 hemoglobin, epsilon 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.