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Hemoglobin, epsilon 1
Protein HBE1 PDB 1a9w.png
PDB rendering based on 1a9w.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HBE1 ; HBE
External IDs OMIM142100 MGI96027 HomoloGene110794 GeneCards: HBE1 Gene
Species Human Mouse
Entrez 3046 15132
Ensembl ENSG00000213931 ENSMUSG00000052217
UniProt P02100 P04444
RefSeq (mRNA) NM_005330 NM_008219
RefSeq (protein) NP_005321 NP_032245
Location (UCSC) Chr 11:
5.27 – 5.51 Mb
Chr 7:
103.84 – 103.84 Mb
PubMed search [1] [2]

Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene.[1]


The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilongamma-Ggamma-Adeltabeta - 3'.[2]

See also[edit]


  1. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166. 
  2. ^ "Entrez Gene: HBE1 hemoglobin, epsilon 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.