HBE1

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HBE1
Protein HBE1 PDB 1a9w.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHBE1, HBE, hemoglobin subunit epsilon 1
External IDsMGI: 96024 HomoloGene: 110794 GeneCards: HBE1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for HBE1
Genomic location for HBE1
Band11p15.4Start5,268,345 bp[1]
End5,505,652 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005330

NM_008219

RefSeq (protein)

NP_005321
NP_005321.1

NP_032245

Location (UCSC)Chr 11: 5.27 – 5.51 MbChr 7: 103.84 – 103.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene.[5]

Function[edit]

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilongamma-Ggamma-Adeltabeta - 3'.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213931 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052217 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. PMID 2649166. 
  6. ^ "Entrez Gene: HBE1 hemoglobin, epsilon 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.