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Hemoglobin, theta 1
Symbols HBQ1 ; HBQ
External IDs OMIM142240 MGI3613460 HomoloGene3895 GeneCards: HBQ1 Gene
RNA expression pattern
PBB GE HBQ1 220807 at tn.png
More reference expression data
Species Human Mouse
Entrez 3049 544763
Ensembl ENSG00000086506 ENSMUSG00000073063
UniProt P09105 Q8BYM1
RefSeq (mRNA) NM_005331 NM_001033981
RefSeq (protein) NP_005322 NP_001029153
Location (UCSC) Chr 16:
0.18 – 0.18 Mb
Chr 11:
32.29 – 32.29 Mb
PubMed search [1] [2]

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.[1][2]

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.[2]


  1. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166. 
  2. ^ a b "Entrez Gene: HBQ1 hemoglobin, theta 1". 

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